indocarbazostatin
an inhibitor of nerve growth stimulated by nerve growth factor; isolated from Streptomyces; structure in first source
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| 1. | Pheochromocytoma
10/01/1999
- " Indocarbazostatin, a novel inhibitor of NGF-induced neurite outgrowth from rat pheochromocytoma PC12 cells." 04/01/2002
- " During the course of our screening for modulators of signal transduction of mammalian cells, we discovered two novel indolocarbazole antibiotics, indocarbazostatin and indocabazostatin B, from a culture broth of a Streptomyces sp. as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells. " 04/01/2002
- " Two novel indolocarbazol-type bioactive molecules, indocarbazostatin (1) and indocarbazostatin B (2), were isolated as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells from a culture broth of a Streptomyces sp. The structures of these compounds were determined by HR-FAB-MS, UV, 1H and 13C NMR, 1H-1H COSY, PFG HMBC, PFG HMQC and DIF NOE experiments. "
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