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BCX 1470

blocks activity of complement enzymes C1s and D in vitro

Also Known As:

2-amidino-6-(2-thiophene carboxy)benzothiophene methanesulfonate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - BCX 1470: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - BCX 1470: 1

Experts

1.	Agrawal, A: 1 article (01/2000)
2.	Babu, Y S: 1 article (01/2000)
3.	Bucy, R P: 1 article (01/2000)
4.	Digerness, S B: 1 article (01/2000)
5.	Kearney, J F: 1 article (01/2000)
6.	Kilpatrick, J M: 1 article (01/2000)
7.	Niwas, S: 1 article (01/2000)
8.	Szalai, A J: 1 article (01/2000)
9.	Volanakis, J E: 1 article (01/2000)

Related Diseases

1.	Edema (Dropsy) 01/01/2000 - "The serine protease inhibitor BCX 1470, which blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. "
2.	Arthus Reaction 01/01/2000 - "These data support the proposal that complement-mediated processes are of major importance in the Arthus reaction in rats and guinea pigs, and suggest that BCX 1470 will be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental."

Related Drugs and Biologics

1.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
2.	Complement Factor D (Factor D)
3.	Enzymes
4.	Complement System Proteins (Complement)
5.	Anti-Inflammatory Agents (Anti-Inflammatories)