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((2- butyl- 3- benzofuranyl)- (5- (2- diethylamino)ethoxy)- 2- thienyl)methanone

structure in first source

Also Known As:

((2-butyl-3-benzofuranyl)-(5-(2-diethylamino)ethoxy)-2-thienyl)methanone hydrochloride; E 047-1

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - ((2-butyl-3-benzofuranyl)-(5-(2-diethylamino)ethoxy)-2-thienyl)methanone: 2

Experts

1.	Domanovits, H: 1 article (05/2000)
2.	Laggner, A N: 1 article (05/2000)
3.	Lercher, P: 1 article (05/2000)
4.	Mayrleitner, M: 1 article (05/2000)
5.	Schillinger, M: 1 article (05/2000)
6.	Stark, T: 1 article (05/2000)
7.	Sterz, F: 1 article (05/2000)
8.	Stix, G: 1 article (05/2000)

Related Diseases

1.	Ventricular Tachycardia 12/01/1999 - "We examined antiarrhythmic effects of the new benzofurane compound E 047/1 on spontaneous ventricular tachyarrhythmia in a conscious dog model. " 12/01/1999 - "The antiarrhythmic E 047/1 has desirable features, suppressing ischemia-induced ventricular tachyarrhythmia quickly and efficiently, and may be a useful addition to current therapeutic regimens. "
2.	Tachycardia (Tachyarrhythmias) 12/01/1999 - "One day after experimental myocardial infarction, 40 dogs exhibiting tachyarrhythmia randomly received (bolus plus 1-h infusion) E 047/1 6 mg/kg plus 6 mg x kg(-1) x h(-1), lidocaine 1 mg/kg plus 4.8 mg x kg(-1) x h(-1), flecainide 1 mg/kg plus 0.05 mg x kg(-1) x h(-1), amiodarone 10 mg/kg plus 1.8 mg x kg(-1) x h(-1), or bretylium 10 mg/kg plus 20 mg x kg(-1) x h(-1). "
3.	Myocardial Infarction 12/01/1999 - "Life-threatening arrhythmias of the heart after myocardial infarction or ischemia may be treated quickly and efficiently by the new drug E 047/1." 12/01/1999 - "One day after experimental myocardial infarction, 40 dogs exhibiting tachyarrhythmia randomly received (bolus plus 1-h infusion) E 047/1 6 mg/kg plus 6 mg x kg(-1) x h(-1), lidocaine 1 mg/kg plus 4.8 mg x kg(-1) x h(-1), flecainide 1 mg/kg plus 0.05 mg x kg(-1) x h(-1), amiodarone 10 mg/kg plus 1.8 mg x kg(-1) x h(-1), or bretylium 10 mg/kg plus 20 mg x kg(-1) x h(-1). "
4.	Ischemia 12/01/1999 - "The effects of the new antiarrhythmic E 047/1 on postoperative ischemia-induced arrhythmias in dogs." 12/01/1999 - "Life-threatening arrhythmias of the heart after myocardial infarction or ischemia may be treated quickly and efficiently by the new drug E 047/1." 12/01/1999 - "The antiarrhythmic E 047/1 has desirable features, suppressing ischemia-induced ventricular tachyarrhythmia quickly and efficiently, and may be a useful addition to current therapeutic regimens. "
5.	Cardiac Arrhythmias (Arrythmia) 05/01/2000 - "E 047/1 has proven to be efficient and safe in the treatment of arrhythmia. " 05/01/2000 - "In an open, nonrandomized prospective multicenter trial, 20 patients were treated with three different i.v. dosage regimens of E 047/1. Arrhythmia termination indicated efficacy. " 05/01/2000 - "The efficacy, pharmacokinetics, safety, and tolerability of E 047/1, an amiodarone derivative, were evaluated in patients with acute supraventricular or ventricular arrhythmia. "

Related Drugs and Biologics

1.	Amiodarone (Amiodarona)
2.	Lidocaine (Xylocaine)
3.	Flecainide (Tambocor)
4.	bretylium