myristamidopropyl dimethylamine

01/01/2022 - "Moreover, the SOF prodrugs do not show cardiotoxicity, the major superiority of AlDox over Dox. "
01/01/2022 - "Phase I-III clinical studies show that aldoxorubicin (AlDox), a prodrug of doxorubicin (Dox), displays reduced cardiotoxicity compared to Dox, but does not demonstrate an overall survival benefit in patients. "

09/01/2007 - "Oxysept 1 Step showed mild activity against the cysts and easyvision one step+ and OPTI-FREE Express with Aldox showed virtually no antiacanthamoeba activity against the cyst form after 6 hours of exposure."
09/01/2007 - "Mean log reductions for cysts were 1.8 for Clear Care/AOSEPT Plus, 2.0 for BLUE Vision/BLUE SEPT, 0.7 for Oxysept 1 Step, 0.5 for OPTI-FREE Express with Aldox, and 0.2 for easyvision one step+. Mean log reductions for trophozoites were 2.2 for Clear Care/AOSEPT Plus, 2.7 for BLUE Vision/BLUE SEPT, 2.5 for Oxysept 1 Step, 2.5 for OPTI-FREE Express with Aldox, and 1.8 for easyvision one step+. Only Clear Care/AOSEPT Plus and BLUE Vision/BLUE SEPT showed high levels of antimicrobial activity against the cyst form of A. "
03/01/2005 - "The multipurpose solution containing polyquaternium-1 and myristamidopropyl dimethylamine reduced more cysts and trophozoites than did the alternative solution tested. "
10/01/2003 - "The effects of age in culture and the type of medium used for induction of Acanthamoeba polyphaga (Ros) cysts on susceptibilities to polyhexamethylene biguanide (PHMB; 3 micro g/ml), chlorhexidine digluconate (30 micro g/ml), myristamidopropyl dimethylamine (20 micro g/ml), H(2)O(2) (3%), and two multipurpose contact lens solutions (MPS-1 and MPS-2, based on 1 micro g of PHMB per ml) were examined. "
01/01/1998 - "The amoebicidal activity of a contact lens multipurpose disinfecting solution (MPDS) containing polyquaternium-1 and myristamidopropyl dimethylamine was compared to a disinfection/neutralisation peroxide system against Acanthamoeba castellanii and Acanthamoeba polyphaga trophozoites and cysts. "

10/09/2018 - "Aldox therapy induced a moderate tumor volume inhibition (TVI) and an increased survival rate (+12.5% vs vehicle). "
01/01/2022 - "The previously established ability of SOFs in overcoming the multidrug resistance of tumor cells is utilized to achieve efficient intracellular delivery of the conjugated AlDox, which releases Dox as an active agent through acid-responsive hydrolysis of the hydrazone bond of AlDox within tumor cells. "

01/01/2012 - "Cell densities were compared among groups by demographic parameters, lens materials, and lens care solutions (polyhexamethylene biguanide [PHMB], polyquaternium-1 and myristamidopropyl dimethylamine [PQ/MAPD], peroxide, or blister pack solution [for daily disposable lenses]). "
01/01/2021 - "Manuscripts written in English were obtained by searching PubMed.gov with the term contact lens plus antimicrobial, benzalkonium chloride, biguanide, Aldox, polyquaternium, preservative, thimerosal, EDTA (ethylenediaminetetraacetic acid), chlorhexidine, or blister pack. "

10/01/2011 - "A care system preserved with Polyquad and Aldox removed higher amounts of CO from senofilcon A contact lenses used for 2 weeks than a peroxide-based system, in soft lens wearers who were symptomatic of dry eye."