|1.||Larsson, Rolf: 9 articles (05/2010 - 04/2002)|
|2.||Larsson, R: 7 articles (08/2002 - 09/2000)|
|3.||Nygren, Peter: 5 articles (05/2010 - 04/2002)|
|4.||Binderup, L: 4 articles (11/2001 - 09/2000)|
|5.||Roulston, Anne: 3 articles (11/2014 - 06/2009)|
|6.||Björkling, Fredrik: 3 articles (01/2010 - 01/2004)|
|7.||Lindhagen, Elin: 3 articles (01/2009 - 01/2004)|
|8.||Binderup, Lise: 3 articles (08/2004 - 01/2004)|
|9.||Jonsson, E: 3 articles (12/2001 - 01/2001)|
|10.||Megally Abdo, Nadia Y: 2 articles (01/2015 - 10/2014)|
09/01/2002 - "A Phase I study of CHS 828 in patients with solid tumor malignancy."
11/01/2001 - "In the present study the fluorometric microculture cytotoxicity assay was used for in vitro evaluation of CHS 828 activity in primary cell cultures from hematological and solid tumors. "
01/01/2015 - "Among these derivatives compounds 2a, 3b and 9c are the most potent, they exhibited cytotoxic effect against the six cancer cell lines with IC(50) values < 330 nM compared to the standard CHS 828. "
06/22/2012 - "Exposure to GMX1778 may be a novel way of inducing ROS selectively in NAPRT1-negative tumors without inducing cytotoxic ROS in normal tissue."
06/22/2012 - "However, as determined by colony formation, GMX1778 long term cytotoxicity in cancer cells was only prevented by the addition of NA to NAPRT1-expressing cells. "
01/01/2009 - "Our results indicate that daily scheduling of CHS 828 may be beneficial in treating patients with high-risk neuroblastoma."
05/01/2002 - "CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs."
01/01/2009 - "The aim of this study was primarily to characterize tumor spread in an orthotopic, metastatic model for aggressive, MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis, tumor growth, and spread. "
05/01/2002 - "Here we report that oral, daily treatment with CHS 828 reduced the growth of SH-SY5Y human neuroblastoma tumors in male NMRI nu/nu mice by 82% without apparent toxicity. "
05/01/2002 - "Combination therapy with CHS 828 and the antiangiogenic drugs TNP-470 or SU5416 decreased neuroblastoma growth by a further 10 and 3%, respectively. "
07/01/2002 - "Metabolic effects of the cytotoxic guanidino-containing drug CHS 828 in human U-937 lymphoma cells."
01/01/2001 - "Here we study the temporal effects of CHS 828 on cytotoxicity, protein and DNA synthesis, cellular morphology and ultra structure using the lymphoma cell line U-937 GTB as the primary tumour model. "
07/01/2002 - "To characterize the metabolic events over time, the lymphoma cell line U-937 GTB was exposed to CHS 828 and the structurally related mitochondrial inhibitor meta-iodobenzylguanidine (MIBG). "
01/01/2001 - "Temporal effects of the novel antitumour pyridyl cyanoguanidine (CHS 828) on human lymphoma cells."
04/15/2002 - "The role of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) and the ADP-ribosylation inhibitor 3-aminobenzamide (3-ABA) in the cytotoxicity induced by the novel antitumoral cyanoguanidine CHS 828 was investigated in the human lymphoma cell line U-937 GTB. "
08/01/2002 - "In this study the fluorometric microculture cytotoxicity assay was used for evaluation of CHS 828 in primary cell cultures from children with acute leukemia. "
08/01/2002 - "Further exploration of CHS 828 in childhood leukemia is warranted, especially in AML."
08/01/2002 - "In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia."
08/20/2004 - "CHS 828 is able to inhibit the lipopolysaccharide (LPS)-induced nuclear localization as well as the transcriptional activity of NF-kappa B in human THP-1 leukemia cells. "
11/01/2001 - "CHS 828 showed high relative in vitro activity against tumor cells from chronic lymphocytic leukemia as well as from acute leukemia and high-grade lymphoma. "
|5.||Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
|3.||N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamide
|4.||1- (2- (2- (2- (2- methoxyethoxy)ethoxy)ethoxy)ethoxycarbonyloxymethyl)- 4- (N'- cyano- N''- (6- (4- chlorophenoxy)hexyl)- N- guanidino)pyridinium
|7.||DNA (Deoxyribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)