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PADRE 45

a synthetic peptide containing amino acid sequences derived from the circumsporozoite protein (CSP) from Plasmodium falciparum

Also Known As:

PADRE peptide; pan HLA DR-binding epitope

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Biological Products
  - Vaccines: 124365
    - Protozoan Vaccines
      - Malaria Vaccines: 895
        PADRE 45: 5

Experts

1.	Bengtsson, Eva: 1 article (01/2021)
2.	Borén, Jan: 1 article (01/2021)
3.	Dunér, Pontus: 1 article (01/2021)
4.	Farina, Christopher: 1 article (01/2021)
5.	Fogelstrand, Per: 1 article (01/2021)
6.	Glise, Lars: 1 article (01/2021)
7.	Jang, Woo-Youl: 1 article (01/2021)
8.	Jung, Shin: 1 article (01/2021)
9.	Jung, Tae-Young: 1 article (01/2021)
10.	Kim, In-Young: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Among adjuvants, pan HLA-DR-binding epitope (PADRE) and anti-programmed cell death protein 1 (anti-PD1) have potentially been tested for cancer immunotherapy. " 11/22/2010 - "We observed that mice vaccinated with E7 peptide-based vaccine in combination with PADRE peptide and poly(I:C) generated better E7-specific CD8+ T cell immune responses as well as significantly improved therapeutic anti-tumor effects against TC-1 tumors compared to E7 peptide-based vaccine with either PADRE peptide or poly(I:C) alone. " 01/01/2015 - "The results show that vaccination with the multi-epitope long peptide in combination with the PADRE peptide and CpG-ODN induced expansion of subpopulations of CD4+ and CD8+ cells producing IFN-γ, the average tumor size in the vaccinated mice was less than that of the other groups, and tumor growth was inhibited in 40% of the mice in the vaccinated group. "
2.	Atherosclerotic Plaque (Atheroma) 01/01/2021 - "Control groups were immunized with PADRE peptide alone or with control murine monoclonal IgG. Immunization with p210-PADRE induced an IgG1 antibody response against p210 that was associated with reduced atherosclerotic plaque formation in the aorta and reduced MDA-LDL content in the lesions. "
3.	Tetanus 12/01/2009 - "Here, based on six copies of the B cell epitope GRP(18-27) in a linear alignment as an immunogen, we designed several anti-GRP DNA vaccines containing different combinations of immunoadjuvants, such as HSP65, tetanus toxoid(830-844) (T), pan HLA-DR-binding epitope (PADRE) (P), and mycobacterial HSP70(407-426) (M), on a backbone of pCR3.1 plasmid vector with eight 5'-GACGTT-3' CpG motifs and the VEGF183 signal peptide (VS). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Vaccines
3.	Poly I-C
4.	Programmed Cell Death 1 Receptor
5.	Protein Sorting Signals (Signal Peptide)
6.	DNA Vaccines
7.	B-Lymphocyte Epitopes (B-Cell Epitope)
8.	Immunoglobulin G (IgG)
9.	Epitopes
10.	Immunologic Adjuvants (Immunologic Adjuvant)

Related Therapies and Procedures

1.	Immunotherapy