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GW395058

thrombopoietin mimetic peptide; amino acid sequence in first source

Also Known As:

GW 395058

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - GW395058: 3

Experts

1.	Case, B C: 1 article (01/2000)
2.	Dillberger, J E: 1 article (01/2000)
3.	Hauck, M L: 1 article (01/2000)
4.	Page, R L: 1 article (01/2000)
5.	Schmith, V D: 1 article (01/2000)
6.	Simkins, A H: 1 article (01/2000)
7.	Yeager, R L: 1 article (01/2000)
8.	de Serres, M: 1 article (01/2000)

Related Diseases

1.	Thrombocytopenia (Thrombopenia) 01/01/2000 - "The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large-animal model (dog) of chemotherapy-induced thrombocytopenia. " 01/01/1999 - "GW395058, a potent PEGylated peptide human thrombopoietin receptor (HuTPOr) agonist in vitro, is being evaluated for the treatment of thrombocytopenia. " 01/01/2000 - "The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia." 01/01/1999 - "GW395058 is a PEGylated peptide thrombopoietin receptor (TPOr) agonist being evaluated for the treatment of chemotherapy-induced thrombocytopenia. "
2.	Hyperplasia 01/01/1999 - "GW395058 caused no immune-mediated lesions in mice, but rHuTPO suppressed megakaryocytopoiesis and caused B-lymphocyte hyperplasia in lymphoid tissues consistent with antigenic stimulation. "

Related Drugs and Biologics

1.	Thrombopoietin Receptors
2.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)