|1.||Wunderink, Richard G: 4 articles (06/2012 - 01/2009)|
|2.||Zwingelstein, Christian: 2 articles (06/2011 - 07/2003)|
|3.||Laterre, Pierre-François: 2 articles (06/2011 - 01/2009)|
|4.||Artigas, Antonio: 2 articles (06/2011 - 07/2003)|
|5.||Doig, Christopher: 2 articles (06/2011 - 07/2003)|
|6.||Opal, Steven: 2 articles (06/2011 - 07/2003)|
|7.||Creasey, Abla A: 2 articles (01/2009 - 07/2003)|
|8.||Abraham, Edward: 2 articles (01/2009 - 07/2003)|
|9.||Poole, Lona: 2 articles (01/2009 - 07/2003)|
|10.||Prous, J R: 2 articles (12/2006 - 04/2006)|
01/01/2008 - "The OPTIMIST phase 3 trial of tifacogin in severe sepsis did not show overall mortality benefit from tifacogin. "
04/01/2004 - "Tifacogin does not reduce mortality in severe sepsis associated with impaired coagulation. "
07/09/2003 - "Treatment with tifacogin had no effect on all-cause mortality in patients with severe sepsis and high INR. "
04/01/2004 - "Whereas antithrombin and tifacogin failed to improve clinical outcome in severe sepsis, drotrecogin alpha (activated) increased the chances of survival of patients with severe sepsis with and without disseminated intravascular coagulation."
05/01/2007 - "Whereas antithrombin and tifacogin failed to improve clinical outcome in cases of severe sepsis, drotrecogin alfa (activated) increased the chances of survival of patients with this condition. "
06/01/2011 - "How tifacogin could not captivate severe community-acquired pneumonia."
01/01/2009 - "A clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia."
01/01/2009 - "The purpose of this analysis was to determine the potential efficacy of recombinant human tissue factor pathway inhibitor (tifacogin) in a subpopulation of patients with community-acquired pneumonia (CAP) from a phase III study of severe sepsis. "
06/01/2012 - "Activation of the coagulation system appears to be a major pathophysiological event in severe pneumonia, but neither drotrecogin alfa activated nor tifacogin (recombinant tissue factor pathway inhibitor) have demonstrated a survival benefit. "
|3.||Disseminated Intravascular Coagulation
07/09/2003 - "Tifacogin administration was associated with an increase in risk of bleeding, irrespective of baseline INR."
07/09/2003 - "There was an increase in serious adverse events with bleeding in the tifacogin group in both cohorts (6.5% tifacogin and 4.8% placebo for high INR; 6.0% tifacogin and 3.3% placebo for low INR). "
01/01/2008 - "In addition to short-term and long-term survival, the study is collecting data on adverse events (particularly when related to bleeding or thrombosis) and the effect of tifacogin on disease progression, resource use, and duration of ICU and hospital stay."
|1.||lipoprotein-associated coagulation inhibitor (TFPI)
|2.||drotrecogin alfa activated (Xigris)