norzoanthamine

heptacyclic marine alkaloid found in Zoanthus; RN given for (4alpha,6abeta,7alpha,9abeta,11beta,13beta,15aalpha,16aalpha,16beta)-(+)-isomer; used to treat osteoporosis; may both suppress bone resorption and enhance bone formation; structure in first source

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Miyashita, Masaaki: 3 articles (05/2012 - 07/2004)
2.	Tanino, Keiji: 3 articles (05/2012 - 07/2004)
3.	Fukuzawa, Seketsu: 2 articles (07/2014 - 01/2014)
4.	Inoue, Hironori: 2 articles (07/2014 - 01/2014)
5.	Tachibana, Kazuo: 2 articles (07/2014 - 01/2014)
6.	Yoshimura, Fumihiko: 2 articles (05/2012 - 07/2009)
7.	Hattori, Izumi: 2 articles (07/2009 - 07/2004)
8.	Sakai, Mio: 2 articles (07/2009 - 07/2004)
9.	Sasaki, Minoru: 2 articles (07/2009 - 07/2004)
10.	Daranas, Antonio Hernández: 1 article (03/2022)

Related Diseases

1.	Osteoporosis 09/01/1999 - "Suppressive effect of norzoanthamine hydrochloride on experimental osteoporosis in ovariectomized mice." 03/01/2022 - "Osteoprotective effect of the marine alkaloid norzoanthamine on an osteoporosis model in ovariectomized rat." 07/01/2014 - "The marine alkaloid norzoanthamine is a candidate drug for osteoporosis treatment. " 01/15/2014 - "The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. " 05/15/2012 - "For example, norzoanthamine inhibits interleukin-6, the key mediator of bone resorption in osteoporosis, providing a promising drug candidate for a disease that affects more than 10 million people over age 50 in the United States. "
2.	Leukemia 07/06/2009 - "Recently, norzoanthamine derivatives were demonstrated to inhibit strongly the growth of P-388 murine leukemia cell lines, in addition to their potent antiplatelet activities on human platelet aggregation. " 07/23/2004 - "Norzoanthamine derivatives can also strongly inhibit the growth of P-388 murine leukemia cell lines and human platelet aggregation. "
3.	Bone Resorption 09/01/1999 - "Based on these results, norzoanthamine hydrochloride may act as both a suppressor of bone resorption and an enhancer of bone formation in vivo." 05/15/2012 - "For example, norzoanthamine inhibits interleukin-6, the key mediator of bone resorption in osteoporosis, providing a promising drug candidate for a disease that affects more than 10 million people over age 50 in the United States. "
4.	Postmenopausal Osteoporosis 09/01/1999 - "We examined the effects of norzoanthamine hydrochloride on bone weight, strength and morphology in ovariectomized mice, a postmenopausal osteoporosis model. "
5.	Inflammation (Inflammations) 07/06/2009 - "Namely, norzoanthamine (1) can suppress the loss of bone weight and strength in ovariectomized mice and has been expected as a promising candidate for a new type of antiosteoporotic drug, while zoanthamine (2) has exhibited potent inhibitory activity toward phorbol myristate-induced inflammation in addition to powerful analgesic effects. "

Related Drugs and Biologics

1.	Alkaloids
2.	Myristic Acid (Tetradecanoic Acid)
3.	Interleukin-6 (Interleukin 6)
4.	Analgesics (Analgesic Drugs)
5.	zoanthamine
6.	phorbol