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RWJ 67657

inhibits p38 mitogen-activated protein kinase; structure in first source

Also Known As:

4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl)-3-butyn-1-ol; RWJ-67657

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - RWJ 67657: 5
  - Pyridines: 88
    - RWJ 67657: 5

Experts

1.	Bai, Ying-Ying: 2 articles (07/2015 - 02/2015)
2.	Chang, Di: 2 articles (07/2015 - 02/2015)
3.	Ju, Shenghong: 2 articles (07/2015 - 02/2015)
4.	Wang, Lishan: 2 articles (07/2015 - 02/2015)
5.	Lu, Chun-Qiang: 1 article (07/2015)
6.	Wang, Guozheng: 1 article (07/2015)
7.	Zhao, Zhen: 1 article (07/2015)
8.	Ding, Jie: 1 article (02/2015)
9.	Li, Cong: 1 article (02/2015)
10.	Peng, Xin-Gui: 1 article (02/2015)

Related Diseases

1.	Stroke (Strokes) 02/01/2015 - "However, the signal intensity of diabetic stroke models significantly increased after oral administration of RWJ 67657, indicating that more transplanted EPCs migrated to the ischemic brain. " 02/01/2015 - "The objectives of this study were to establish a non-invasive imaging strategy to monitor the homing of transplanted EPCs in diabetic stroke mice and to assess the effect of RWJ 67657, an inhibitor of p38 MAPK, on the homing ability of exogenous EPCs. " 07/01/2015 - "RWJ 67657 (RWJ), a p38 mitogen-activated protein kinase inhibitor, was administered orally for 7 consecutive days, with the first dose given 30 minutes before stroke induction. "
2.	Left Ventricular Dysfunction 10/19/2004 - "The aim of this study was to examine the effect of the p38 mitogen-activated protein kinase (MAPK) inhibitor, RWJ-67657 (RWJ), on left ventricular (LV) dysfunction and remodeling post-myocardial infarction (MI) in rats. "
3.	Myocardial Infarction 10/19/2004 - "The aim of this study was to examine the effect of the p38 mitogen-activated protein kinase (MAPK) inhibitor, RWJ-67657 (RWJ), on left ventricular (LV) dysfunction and remodeling post-myocardial infarction (MI) in rats. "
4.	Sepsis (Septicemia) 04/01/2001 - "We conclude that inhibition of p38MAPK by RWJ-67657 might be a tool to intervene in the deranged immune response in sepsis and other inflammatory diseases."
5.	Cerebral Toxoplasmosis 10/20/2023 - "RWJ-67657 emerges as a valuable drug candidate for experimental chronic cerebral toxoplasmosis therapy."

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration