monastrol

01/01/2020 - "Results & conclusion: DHPMs 9, 13 and 17 have been identified as having improved activity against glioma and bladder cell lines as compared with monastrol. "
08/01/2018 - "Synthesis and antitumoral activity of novel analogues monastrol-fatty acids against glioma cells."
06/01/2018 - "Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines."
04/01/2014 - "We describe the effect of LaSOM 63, a monastrol derivative, on ecto-5'NT activity and on glioma cell survival. "
10/01/2013 - "Here we describe the effect of LaSOM 65, a monastrol derivated compound, against glioma cell lines. "

08/16/2008 - "The title compound, C(15)H(16)N(2)O(5), belongs to the class of monastrol-type anti--cancer agents and was selected for crystal structure determination in order to determine the conformational details needed for subsequent structure-activity relationship studies. "
12/01/2016 - "These results provide evidence that monastrol has a greater antiproliferative effect on MCF-7 tumor cells compared with non-tumor HB4a cells; however, no selective is observed."
12/01/2016 - "Monastrol treatment decreased cell viability only in MCF-7 tumor cells. "
05/01/2013 - "Monastrol, known to cause mitotic arrest in cancer cells, inhibited Rap1A prenylation (geranylgeranylation) in intracellular Leishmania, which resulted in blockade at the G1 phase of the cell cycle. "
04/15/2012 - "The antiproliferative activity against cancer cells was disclosed for the first time for 16 monastrol analogs. "

10/01/2018 - "Taken together, the data reveal a regulatory mechanism by circRNA‑MTO1 to control cell viability and monastrol resistance in breast cancer cells."
10/01/2018 - "Monastrol-resistant cell lines were established by exposing breast cancer cells to increasing concentrations of monastrol. "
10/01/2018 - "The present study sought to determine the expression profiles and potential modulatory role of circRNAs on breast cancer cell viability and monastrol resistance. "
10/01/2018 - "Circular RNA‑MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis."
02/01/2013 - "The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines."

11/01/2017 - "Cytotoxicity studies in leukemia and multiple myeloma cell lines showed no interference of monastrol with the cytostatic effects of bortezomib. "

11/01/2017 - "Cytotoxicity studies in leukemia and multiple myeloma cell lines showed no interference of monastrol with the cytostatic effects of bortezomib. "