|1.||Russowsky, Dennis: 3 articles (04/2014 - 08/2006)|
|2.||Baas, Peter W: 2 articles (01/2015 - 05/2004)|
|3.||Mendes, Franciane Brackmann: 2 articles (04/2014 - 10/2013)|
|4.||Eifler-Lima, Vera Lucia: 2 articles (04/2014 - 10/2013)|
|5.||Battastini, Ana Maria Oliveira: 2 articles (04/2014 - 10/2013)|
|6.||Figueiró, Fabrício: 2 articles (04/2014 - 10/2013)|
|7.||de Fátima, Angelo: 2 articles (04/2012 - 08/2006)|
|8.||Veizerová, Lucia: 2 articles (01/2008 - 01/2008)|
|9.||Světlík, Jan: 2 articles (01/2008 - 01/2008)|
|10.||Kettmann, Viktor: 2 articles (01/2008 - 01/2008)|
01/01/2015 - "Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol."
05/01/2013 - "Monastrol, known to cause mitotic arrest in cancer cells, inhibited Rap1A prenylation (geranylgeranylation) in intracellular Leishmania, which resulted in blockade at the G1 phase of the cell cycle. "
04/15/2012 - "The antiproliferative activity against cancer cells was disclosed for the first time for 16 monastrol analogs. "
02/07/2012 - "The role of spindle elongation motors in merotelic correction is conserved, because partial inhibition of the human kinesin-5 homolog Eg5 using the drug monastrol reduces spindle length and lagging chromosome frequency in both normal (RPE-1) and tumor (CaCo-2) cells. "
08/01/2011 - "These dimers have been evaluated for cytotoxic potency against selected human cancer cell lines and some of the compounds have exhibited more cytotoxic potency than the parent monastrol. "
04/01/2014 - "In contrast to monastrol, LaSOM 63 did not cause glioma cell-cycle arrest, but inhibited ecto-5'NT enzyme activity. "
04/01/2014 - "We describe the effect of LaSOM 63, a monastrol derivative, on ecto-5'NT activity and on glioma cell survival. "
10/01/2013 - "Here we describe the effect of LaSOM 65, a monastrol derivated compound, against glioma cell lines. "
04/01/2014 - "A monastrol-derived compound, LaSOM 63, inhibits ecto-5'nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines."
|3.||Glioblastoma (Glioblastoma Multiforme)
10/01/2013 - "Activity of LaSOM 65, a monastrol-derived compound, against glioblastoma multiforme cell lines."
02/01/2007 - "Compared to monastrol, the new cell cycle specific compounds showed an at least one order of magnitude higher anti proliferative activity against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells. "
02/01/2007 - "Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells."
02/01/2007 - "Therefore, we studied the effects of the new monastrol analogues enastron, dimethylenastron and vasastrol VS-83 on the proliferation of human glioblastoma cells in the kinetic crystal violet assay. "
01/01/2013 - "In the absence of Eg5, which is a target of monastrol, overexpression of p31(comet) caused premature destruction of Securin and premature sister chromatid separation, but it did not cause aneuploidy. "
04/11/2004 - "Also, significant (P < 0.05) increases in the frequencies of monoastral spindles and chromosome displacement from the metaphase plate were found in oocytes during meiosis I. In metaphase II oocytes, monastrol significantly (P < 0.05) increased the frequencies of premature centromere separation and aneuploidy. "
04/11/2004 - "Transient exposure to the Eg5 kinesin inhibitor monastrol leads to syntelic orientation of chromosomes and aneuploidy in mouse oocytes."
01/01/2013 - "Here, we showed that the overexpression of p31(comet) can abolish the Mad2-dependent SAC that is induced by anti-mitotic drugs, including nocodazole, taxol, and monastrol; these drugs, except monastrol, cause aneuploidy in HeLa cells. "
|5.||Spinal Cord Injuries (Spinal Cord Injury)
|1.||C 15 (C-15)
|5.||Small Interfering RNA (siRNA)
|6.||5'-Nucleotidase (5' Nucleotidase)
|7.||Gentian Violet (Violet, Crystal)
|8.||Mosaic variegated aneuploidy syndrome