|1.||Alhonen, Leena: 7 articles (07/2014 - 01/2006)|
|2.||Nordback, Isto: 4 articles (01/2011 - 01/2006)|
|3.||Herzig, Karl-Heinz: 4 articles (01/2011 - 01/2006)|
|4.||Sand, Juhani: 4 articles (01/2011 - 01/2006)|
|5.||Jin, Hai-Tao: 3 articles (01/2011 - 01/2008)|
|6.||Hyvönen, Mervi T: 3 articles (01/2011 - 01/2006)|
|7.||Porter, Carl W: 3 articles (07/2010 - 06/2004)|
|8.||Casero, Robert A: 3 articles (01/2007 - 08/2004)|
|9.||Pirnes-Karhu, Sini: 2 articles (07/2014 - 02/2012)|
|10.||Uimari, Anne: 2 articles (07/2014 - 02/2012)|
10/20/1995 - "The detection of cytosolic spermidine N8-acetyltransferase activity in tumors may thus represent the expression of a fetal gene that does not seem to have a particular function during carcinogenesis."
08/01/2004 - "The response of solid tumors to this drug has been associated with superinduction of the polyamine catabolic enzyme, spermine/spermidine N1-acetyltransferase (SSAT). "
01/01/1989 - "In the study of ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermidine acetyltransferase activities and of polyamine concentration in tumors of the oral cavity we have shown a marked increase in the tumor cells. "
11/01/2010 - "Similar to sulindac, OXT-922 enhanced spermidine/spermine N(1)-acetyltransferase activity, reduced the cellular polyamine content and synergized with difluoromethylornithine to inhibit cancer cell proliferation and induce apoptosis. "
07/01/2014 - "Spermidine/spermine N(1)-acetyltransferase (SSAT), which regulates intracellular levels of polyamines by catabolizing spermidine and spermine, has a controversial role in the development of cancers. "
01/01/2010 - "We have previously shown that pancreatic polyamine depletion in rats overexpressing the catabolic enzyme, spermidine/spermine N(1)-acetyltransferase (SSAT), results in the development of severe acute pancreatitis, and that therapeutic administration of metabolically stable alpha-methylated polyamine analogs protects the animals from pancreatitis-associated mortality. "
01/01/2008 - "Acute experimental pancreatitis is associated with an early pancreatic spermidine/spermine N(1)-acetyltransferase induction and consequent changes in polyamine levels in pancreas and red blood cells, depending on the severity of pancreatitis. "
01/01/2006 - "Activation of polyamine catabolism in transgenic rats overexpressing spermidine/spermine N(1)-acetyltransferase, the key enzyme in polyamine catabolism, results in severe acute pancreatitis. "
01/01/2011 - "Pancreatitis was induced in wild-type rats by 2 or 6% taurodeoxycholate infusion or in transgenic rats by overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT). "
02/01/2012 - "In this study, the wild-type mice, polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase overexpressing (SSAT mice) and SSAT-deficient mice were used to characterize the new zinc-induced acute pancreatitis mouse model and study the role of polyamines and polyamine catabolism in this model. "
03/01/2007 - "Expression of spermidine/spermine N(1)-acetyltransferase (SSAT) increases in kidneys subjected to ischemia-reperfusion injury (IRI). "
07/01/2010 - "The expression of catabolic enzymes spermidine/spermine N(1)-acetyltransferase (SSAT) and spermine oxidase (SMO) increases after ischemic reperfusion injury. "
|4.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2007 - "We identified the polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) as being one of the most highly inducible genes in two DNA microarray screens to identify novel determinants of response to chemotherapeutic agents in colorectal cancer. "
07/01/2012 - "The co-treatment with celecoxib enhanced NPC-16-induced apoptosis in HCT116 (COX-2 no expression), HT29 (COX-2 higher expression) and Caco-2 (COX-2 higher expression) colorectal cancer cells, which was mediated by the elevated NPC-16 uptake via the effect of celecoxib on polyamine metabolism, including the up-regulated spermidine/spermine N(1)-acetyltransferase (SSAT) activity and reduced intracellular polyamine levels. "
|1.||Ornithine Decarboxylase (Decarboxylase, Ornithine)
|10.||diamine N-acetyltransferase (spermidine acetyltransferase)