|1.||Maruyama, Takayuki: 4 articles (03/2007 - 07/2003)|
|2.||Wakabayashi, Keiji: 3 articles (03/2007 - 07/2003)|
|3.||Omote, Keiichi: 3 articles (06/2004 - 11/2002)|
|4.||Nakayama, Yoshito: 3 articles (06/2004 - 11/2002)|
|5.||Namiki, Akiyoshi: 3 articles (06/2004 - 11/2002)|
|6.||Mutoh, Michihiro: 2 articles (03/2007 - 05/2005)|
|7.||Ohuchida, Shuichi: 2 articles (05/2005 - 07/2003)|
|8.||Sugimura, Takashi: 2 articles (05/2005 - 07/2003)|
|9.||Kitamura, Tomohiro: 2 articles (05/2005 - 07/2003)|
|10.||Kawamata, Tomoyuki: 2 articles (06/2004 - 12/2002)|
12/01/2002 - "We designed the present study to determine whether the intrathecal administration of an antagonist for prostaglandin E(2) receptor subtype EP(1), ONO-8711, has an analgesic effect on incision-induced mechanical and thermal hyperalgesia. "
06/04/2004 - "Intrathecal administration of ONO-8711 attenuated the PGE2-induced mechanical hyperalgesia in a dose- and time-dependent manner. "
11/01/2002 - "The hyperalgesia was inhibited by intrathecal ONO-8711 in the late, but not early, phase. "
01/01/2001 - "We examined whether a peripherally administered novel selective EP(1) antagonist, ONO-8711, would be a potential analgesic for incision-induced mechanical hyperalgesia. "
11/01/2002 - "The effect of an intrathecally administered selective EP1 antagonist, ONO-8711, on the carrageenan-induced hyperalgesia was examined. "
|2.||Colonic Neoplasms (Colon Cancer)
05/01/2005 - "In the present study, we investigated the long-term effects of ONO-8711 on colon cancer development in rats treated with AOM. "
11/01/2001 - "Our finding that ONO-8711 significantly suppresses colonic ACF formation and cell proliferation strengthens the hypothesis that the selective prostaglandin E receptor EP1 antagonists possesses chemopreventive activity against colon cancer development."
|3.||Aberrant Crypt Foci
11/01/2001 - "This study was designed to determine the chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344 rats and to compare its potential with that of nimesulide, a well-documented selective COX-2 inhibitor. "
|4.||Breast Neoplasms (Breast Cancer)
12/01/2001 - "Apoptosis was significantly increased in breast cancer cells by feeding of ONO-8711 at 800 p.p.m. "
12/01/2001 - "Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development."
12/01/2001 - "The present study was designed to investigate the effects of ONO-8711, a newly synthesized selective PGE receptor EP(1) antagonist, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced breast cancer development. "
05/01/2005 - "ONO-8711 also reduced the numbers of intestinal polyps in Min mice. "
07/01/2003 - "ONO-8711 and ONO-AE2-227, prostaglandin E receptor subtype EP(1)- and EP(4)-selective antagonists, respectively, are known to suppress formation of intestinal polyps in adenomatous polyposis coli gene-deficient mice. "
10/15/1999 - "Moreover, when Min mice, having a nonsense mutation in the adenomatous polyposis coli gene, were given 500 ppm ONO-8711 in the diet, the number of intestinal polyps was significantly reduced to 57% of that in the basal diet group. "
|1.||Prostaglandin E Receptors (Prostaglandin E Receptor)
|4.||2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridine
|6.||Small Interfering RNA (siRNA)
|7.||Acetic Acid (Vinegar)
|8.||Nonsense Codon (Nonsense Mutation)
|10.||Prostaglandins E (PGE)