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recombinant methionyl human leptin

Also Known As:
r-MetHUleptin
Networked: 27 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mantzoros, Christos S: 10 articles (02/2013 - 05/2003)
2. Chan, Jean L: 8 articles (02/2009 - 05/2003)
3. Gorden, Phillip: 7 articles (04/2008 - 02/2002)
4. DePaoli, Alex M: 6 articles (05/2005 - 02/2002)
5. Depaoli, Alex M: 5 articles (09/2007 - 07/2002)
6. Oral, Elif Arioglu: 4 articles (04/2005 - 02/2002)
7. Lee, Jennifer H: 3 articles (02/2009 - 06/2004)
8. Wong, Ma-Li: 3 articles (12/2008 - 05/2005)
9. Licinio, Julio: 3 articles (12/2008 - 05/2005)
10. Cochran, Elaine K: 3 articles (04/2008 - 04/2005)

Related Diseases

1. Insulin Resistance
2. Lipodystrophy
3. Weight Loss (Weight Reduction)
09/01/2007 - "To compliment the acute study, we retrospectively analyzed available BP results from a previously performed 85-day, placebo-controlled, randomized, double-blind, parallel weight-loss study using r-metHuLeptin in 284 obese adults. "
12/01/2008 - "The female patient with type 2 diabetes became euglycemic after treatment with r-metHuLeptin and subsequent weight loss. "
09/01/2007 - "In the retrospective analysis of the weight loss study data, 10 mg every day before noon (QAM), 10 mg every day after noon (QPM), or 10 mg twice a day (BID) SC of r-metHuLeptin was found to not alter the degree of weight loss (-3.2 +/- 3.7 versus -2.9 +/- 3.2 Kg, P = .54), change in systolic (-1.6 + 12.9 versus -2.0 +/- 13.9 mmHg, P = .85) and diastolic BP (-0.2 +/- 8.7 versus -1.5 +/- 8.6, P = .30), as well as heart rate (-1.4 +/- 10.7 versus -1.4 +/- 10.4 beats/min, P = .98) compared to placebo. "
10/01/2012 - "However, if r-metHuLeptin treatment has been shown to be dramatically efficient in leptin-deficient states, its very limited effect in inducing weight loss in common obese patients revealed that, in patients with adequate leptin secretion, mechanisms of leptin resistance and leptin tolerance prevent r-metHuLeptin from inducing any additional effects. "
01/01/2008 - "Within each group, the subjects lost approximately 3-4 kg of bodyweight after 3 days of fasting (all p < 0.0001), but the amount and time course of weight loss did not differ according to the dose of r-metHuLeptin administered or the circulating leptin concentrations achieved. "
4. Metabolic Diseases (Metabolic Disease)
5. Donohue Syndrome

Related Drugs and Biologics

1. Leptin
2. recombinant methionyl human leptin
3. Insulin (Novolin)
4. Berardinelli-Seip congenital lipodystrophy type 2
5. Lamin Type A (Lamin A)
6. Lipoproteins (Lipoprotein)
7. metreleptin
8. P-30 composite resin (P 30)
9. Insulin-Like Growth Factor I (IGF-1)
10. Glucose (Dextrose)

Related Therapies and Procedures

1. Highly Active Antiretroviral Therapy (HAART)
2. Injections
3. Aftercare (After-Treatment)