|1.||Santin, Alessandro D: 10 articles (12/2015 - 10/2004)|
|2.||Pecorelli, Sergio: 8 articles (12/2015 - 10/2004)|
|3.||Morin, Patrice J: 8 articles (05/2008 - 07/2003)|
|4.||Bellone, Stefania: 7 articles (12/2015 - 10/2004)|
|5.||Sawada, Norimasa: 5 articles (11/2013 - 07/2007)|
|6.||Agarwal, Rachana: 5 articles (05/2008 - 07/2003)|
|7.||Cocco, Emiliano: 4 articles (12/2015 - 01/2010)|
|8.||Koo, Ja Seung: 4 articles (02/2015 - 11/2012)|
|9.||D'Souza, Theresa: 4 articles (11/2007 - 07/2003)|
|10.||Schwartz, Peter E: 3 articles (12/2015 - 01/2010)|
01/01/2013 - "Using a Salmonella-colitis mouse model and cultured colonic epithelial cells, we found that pathogenic Salmonella colonization significantly increases the levels of claudin-2 protein and mRNA in the intestine, but not that of claudin-3 or claudin-7 in the colon, in a time-dependent manner. "
01/01/2014 - "In DSS colitis model, occludin and claudin-3 expression significantly decreased compared with the control mice (P<0.05); and octreotide treatment could only significantly upregulate claudin-3 expression compared with untreated DSS colitis mice (P<0.05). "
06/01/2013 - "DSS administration also impaired TJ barrier integrity in the colon, as indicated by increased colon permeability and plasma LPS-binding protein levels, resulting from the impaired colonic expression of TJ proteins, occludin, junctional adhesion molecule-A, and claudin-3. Supplemental feeding with naringenin totally or partially attenuated these symptoms, suggesting that naringenin ameliorates the DSS-induced colitis at least partially through protection of the TJ barrier. "
01/01/2015 - "Human claudin-3 (CLDN3) is a tetraspanin transmembrane protein of tight junction structures and is known to be over-expressed in some malignant tumors. "
09/01/2014 - "It has been shown for the first time that SPTs are characterized by the nuclear expression of claudin 3 and the cytoplasmic expression of claudin 7. It has been also ascertained that the aberrant perinuclear (dot-like) expression of CD99 is a unique feature of these tumors. "
01/01/2012 - "The toxin is especially lethal for cells expressing large amounts of claudin-3 or -4, which includes many cancer cells. "
03/03/2009 - "Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. "
01/01/2009 - "In addition, claudin-3 and -4 expression in rectal well-differentiated endocrine neoplasms suggests the possibility of a new therapeutic strategy. "
|3.||Ovarian Neoplasms (Ovarian Cancer)
04/01/2014 - "Claudin-3 (CLDN3), a commonly upregulated gene in 90% of ovarian cancers, has been identified as a novel therapeutic target of ovarian cancer. "
12/15/2011 - "Real-time polymerase chain reaction and flow cytometry were used to evaluate claudin-3/-4 expression in ovarian cancer stem cells. "
07/01/2011 - "Claudin-3 (CLDN3) is a recently discovered gene generally overexpressed in human ovarian cancers but not in normal ovarian tissue. "
07/15/2005 - "Here, we showed that claudin-3 and -4 can be phosphorylated in ovarian cancer cells. "
11/01/2007 - "Our data provide a basis for CLDN3 expression in ovarian cancer cells, as well as a mechanism for the silencing of this promoter in tumors lacking expression of claudin-3."
|4.||Stomach Neoplasms (Stomach Cancer)
01/01/2014 - "Our data suggest that the up-regulation of claudin-3 and claudin-7 and the down-regulation of claudin-18 may play a role in the carcinogenesis of gastric cancer. "
01/01/2014 - "Claudin-3 and claudin-7 were expressed in 25.4% and 29.9% of the gastric cancer tissues, respectively. "
06/01/2012 - "Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers."
01/01/2014 - "The purpose of this study was to evaluate the expression of claudin-3, claudin-7, and claudin-18 in gastric cancer and to determine the significance of these proteins for patient outcome. "
01/01/2015 - "In addition, the expression of claudin-3 is correlated with claudin-4 expression in gastric cancer. "
|5.||Prostatic Neoplasms (Prostate Cancer)
09/01/2014 - "A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells."
01/01/2011 - "These findings provide further evidence that claudin-3 may serve as an important biomarker for prostate cancer, both primary and metastatic, but does not provide evidence that claudin-3 can be used to predict risk of metastasis."
11/01/2001 - "The persistent high level of claudin-3 expression in prostate adenocarcinoma and functional cytotoxicity of CPE in metastatic androgen-independent prostate adenocarcinoma suggests a new potential therapeutic strategy for prostate cancer."
11/01/2001 - "The present study was designed to study the expression of claudin-3 and claudin-4 in human prostate tissue as potential targets for CPE toxin-mediated therapy for prostate cancer. "
11/01/2005 - "In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. "
|1.||Proteins (Proteins, Gene)
|4.||junctional adhesion molecule
|7.||claudin 1 (CLDN1)
|9.||Messenger RNA (mRNA)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)