7,3'-dihydroxy-4'-methoxyisoflavone

08/10/2023 - "BHD and Calycosin both effectively improved mNSS scores with smaller infarct volumes. "
01/01/2023 - "Calycosin pretreatment reduced infarct volume and improved neurological outcome in rats subjected to MCAO. "
01/01/2018 - "The results showed that calycosin pretreatment for 14 days markedly decreased infarct volume and brain edema, and ameliorated neurological scores in rats with focal cerebral ischemia and reperfusion. "
12/18/2012 - "Treatment with calycosin significantly ameliorated neurologic deficit and infarct volume after cerebral ischemia reperfusion. "
05/01/2020 - "Calycosin reduces infarct size, oxidative stress and preserve heart function in isoproterenol-induced myocardial infarction model."

04/15/2014 - "Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats."
01/01/2021 - "This study was designed to understand the pivotal anti-cerebral ischemia/reperfusion injury (CIRI) targets and pathways of calycosin through network pharmacology and molecular docking analyses. "
07/01/2023 - "Calycosin alleviates cerebral ischemia/reperfusion injury by repressing autophagy via STAT3/FOXO3a signaling pathway."
01/01/2023 - "Calycosin decreases cerebral ischemia/reperfusion injury by suppressing ACSL4-dependent ferroptosis."
01/01/2023 - "But the effect of calycosin on cerebral ischemia-reperfusion injury has not been fully elucidated. "

03/04/2019 - "Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-κB Pathway In Vitro and In Vivo."
01/01/2017 - "The aim of this study was to explore the mechanism of calycosin on epithelial cells in allergic inflammation. "
11/07/2022 - "This finding suggests that the beneficial effects of ABZ plus calycosin treatment on the regulation of inflammation are mediated by the modulation of HO-1 activation. "
10/28/2022 - "Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways."
06/01/2022 - "As a conclusion, calycosin prevents IL-1β-induced chondrocyte apoptosis, inflammation, and ECM degradation through inactivating the PI3K/AKT/FoxO1 pathway."

01/01/2022 - "This study aimed to explore the anti-tumor ability of calycosin on human PTC and its potential mechanisms. "
03/01/2020 - "In vivo study has confirmed that calycosin would provoke the pro-invasive and angiogenic drive and subsequent EMT in pancreatic tumors. "
11/01/2019 - "Calycosin (CC) is evidenced in our previous study to play the anti-OS benefits for suppressing cancer cell proliferation. "
09/01/2015 - "In this study, we aimed to investigate the anti-tumor activities of calycosin on CRC and its potential mechanism. "
07/01/2015 - "Recently, several studies have shown that calycosin can inhibit growth and induce apoptosis in human cancer cell lines; however, the mechanisms are not completely clarified yet. "

01/01/2021 - "In this study, we investigated the effects of calycosin on breast cancer cell progression and their underlying mechanisms. "
08/01/2013 - "And for the first time, this study revealed that calycosin may have potential as a therapeutic agent for the treatment of breast cancer. "
01/01/2022 - "Correction for: Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERα."
01/01/2021 - "This suggests calycosin would be a promising therapeutic option for breast cancer patients."
01/01/2021 - "Our findings demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFβ1 signaling. "