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AHN 649

a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist

Also Known As:

AHN649

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Ischemia 10/01/1999 - "Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist."
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/01/1999 - "AHN649, an analog of dextromethorphan (DM) and a relatively selective low-affinity N-methyl-D-aspartate antagonist, was evaluated for neuroprotective effects using the rat intraluminal filament model of temporary middle cerebral artery occlusion. "
3.	Infarction (Infarctions) 10/01/1999 - "Post-treatment with AHN649 (0.156-20 mg/kg i.v.) or DM (0.156-10 mg/kg i.v.) significantly reduced cortical infarct volume by 40 to 60% compared with vehicle-control treatments. "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Dextromethorphan (Racemethorphan)
3.	Neuroprotective Agents