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AHN 649
a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist
Also Known As:
AHN649
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Opiate Alkaloids: 5944
Morphinans: 33
Dextromethorphan: 753
AHN 649: 1
Bridged-Ring Heterocyclic Compounds
Morphinans: 33
Dextromethorphan: 753
AHN 649: 1
Fused-Ring Heterocyclic Compounds
4 or More Rings Heterocyclic Compounds
Morphinans: 33
Dextromethorphan: 753
AHN 649: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
Morphinans: 33
Dextromethorphan: 753
AHN 649: 1
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Excitatory Amino Acids: 1301
AHN 649: 1
Related Diseases
1.
Ischemia
10/01/1999 - "
Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist.
"
2.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/01/1999 - "
AHN649, an analog of dextromethorphan (DM) and a relatively selective low-affinity N-methyl-D-aspartate antagonist, was evaluated for neuroprotective effects using the rat intraluminal filament model of temporary middle cerebral artery occlusion.
"
3.
Infarction (Infarctions)
10/01/1999 - "
Post-treatment with AHN649 (0.156-20 mg/kg i.v.) or DM (0.156-10 mg/kg i.v.) significantly reduced cortical infarct volume by 40 to 60% compared with vehicle-control treatments.
"
Related Drugs and Biologics
1.
N-Methylaspartate (NMDA)
2.
Dextromethorphan (Racemethorphan)
3.
Neuroprotective Agents