|1.||Greig, Nigel H: 3 articles (05/2009 - 11/2002)|
|2.||Greig, N H: 2 articles (07/2015 - 04/2001)|
|3.||Harada, Mamoru: 2 articles (04/2013 - 01/2013)|
|4.||Harashima, Nanae: 2 articles (04/2013 - 01/2013)|
|5.||Hato, Takashi: 2 articles (01/2013 - 01/2012)|
|6.||Plotkin, Zoya: 2 articles (01/2013 - 01/2012)|
|7.||Sutton, Timothy A: 2 articles (01/2013 - 01/2012)|
|8.||Dagher, Pierre C: 2 articles (01/2013 - 01/2012)|
|9.||Wu, Shu-Jing: 2 articles (01/2011 - 12/2007)|
|10.||Ng, Lean-Teik: 2 articles (01/2011 - 12/2007)|
11/01/2010 - "Pifithrin-α (PFT-α), a specific inhibitor of p53, has been suggested as a combinatory agent in the treatment of p53-deficient tumors in which inhibition of p53 would not compromise therapeutic efficacy but would decrease p53-mediated side effects in normal tissue. "
06/01/2008 - "In this study, we used cyclic pifithrin-alpha, a transcriptional inhibitor of p53, to further investigate the relevance of p53 function in the response of tumor cells to microtubule inhibitors. "
03/01/2004 - "This study demonstrates that PFT-alpha effectively inhibits DOX-induced cardiomyocyte apoptosis, which suggests that PFT-alpha has the potential to protect cancer patients against DOX-induced cardiac injury."
10/01/2014 - "2-Phenylethynesulfonamide (PES) or pifithrin-μ is a promising anticancer agent with preferential toxicity for cancer cells. "
09/05/2014 - "Down-regulated the expression of tumor suppressor p53 by 10 μM pifithrin-α (PFTα) alone had no effect on adipose accumulation. "
07/01/2015 - "The p53 inactivator pifithrin-α (PFT-α) has been shown to be neuroprotective against stroke. "
02/01/2013 - "Pifithrin-α enhances the survival of transplanted neural stem cells in stroke rats by inhibiting p53 nuclear translocation."
05/01/2009 - "Delayed treatment with a p53 inhibitor PFT-alpha is able to modify stroke-induced endogenous neurogenesis and improve the functional recovery in stroke animals."
05/01/2009 - "PFT-alpha inhibited the expression of a p53-dependent proapoptotic gene, termed PUMA (p53-upregulated modulator of apoptosis), within the SVZ of stroke animals. "
02/01/2013 - "We compared the effects of vehicle + NSCs and FFT-α + NSCs on the efficacy of transplantation in stroke rat model using behavioral analysis, immunohistochemistry, etc. Pifithrin-α increased viability and decreased apoptosis in NSCs after OGD in vitro. "
03/01/2014 - "The hypersensitivity to CPT treatment was markedly reduced by blocking p53 translocation to mitochondria with pifithrin-μ. "
10/01/2004 - "Furthermore, the low-dose hypersensitivity and Annexin V binding to irradiated A549 and T98G cells were eliminated by treating the cells with pifithrin, an inhibitor of p53. "
11/01/2010 - "Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells."
12/15/2007 - "Inactivation of p53 by pifithrin-alpha or siRNA down-regulation sensitized p53wt but not p53mt glioma cells to ACNU and BCNU. "
|3.||Tumor Suppressor Protein p53
|7.||Mitogen-Activated Protein Kinases
|8.||Cadmium Chloride (Cadmium Dichloride)
|10.||Biological Markers (Surrogate Marker)
|2.||Transplantation (Transplant Recipients)
|3.||Drug Therapy (Chemotherapy)