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6-methyl-2-(phenylethynyl)pyridine

an mGlu5 antagonist

Also Known As:

2-methyl-6-(phenylethynyl)pyridine; MPEP cpd

Networked: 12 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 6-methyl-2-(phenylethynyl)pyridine: 12

Experts

1.	Huang, Gan: 1 article (01/2021)
2.	Taylor, Jane R: 1 article (01/2021)
3.	Thompson, Summer L: 1 article (01/2021)
4.	Florek-Luszczki, Magdalena: 1 article (02/2016)
5.	Kondrat-Wrobel, Maria W: 1 article (02/2016)
6.	Luszczki, Jarogniew J: 1 article (02/2016)
7.	Zolkowska, Dorota: 1 article (02/2016)
8.	Desrayaud, Sandrine: 1 article (03/2013)
9.	Di Paolo, Thérèse: 1 article (03/2013)
10.	Gasparini, Fabrizio: 1 article (03/2013)

Related Diseases

1.	Cocaine-Related Disorders (Cocaine Addiction) 11/01/2008 - "Similarly, the mGluR1/5 antagonists, 2-methyl-6-(phenylethynyl)pyridine and 3-[2-methyl-4-thiazolyl)ethynyl]pyridine, have shown to be effective in preclinical models of cocaine addiction. "
2.	Hypersensitivity (Allergy) 08/01/2007 - "This study used the metabotropic glutamate 5 (mGlu5) receptor subtype-selective antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) to characterise the contribution of mGlu5 receptor activity to pain and hypersensitivity in an animal model of post-surgical pain. " 04/25/2007 - "Subsequent behavioral studies demonstrated that the group I mGluR agonist, R,S-3,5-dihydroxyphenylglycol (DHPG), significantly decreased the mechanical threshold to noxious stimulation of the masseter, and that the DHPG-induced mechanical hypersensitivity can be effectively prevented by pretreatment of the masseter with 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), a selective mGluR 5 antagonist, but not by 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt), a selective mGluR 1 antagonist. "
3.	Seizures (Absence Seizure) 08/22/2003 - "The competitive, phenylglycine mGlu1/5 receptor antagonists generally require intracerebroventricular administration for potent anticonvulsant efficacy but noncompetitive antagonists, e.g., (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydrocyclopenta[c]furan-1-on (BAY36-7620), 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), and 2-methyl-6-(2-phenylethenyl)pyridine (SIB-1893) block generalized seizures with systemic administration. " 09/01/2011 - "Here, we tested the mGluR5-positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB), the mGluR5 inverse agonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), and GABA(B) receptor agonists, alone and in combination on receptor protein expression and audiogenic seizures in FMR1 mice. " 02/04/2016 - "The aim of this study was to determine the effects of 2-methyl-6-(phenylethynyl)pyridine (MPEP - a selective antagonist for the glutamate metabotropic receptor subtype mGluR5) on the protective action of some novel antiepileptic drugs (lamotrigine, oxcarbazepine, pregabalin and topiramate) against maximal electroshock-induced seizures in mice. "
4.	Pain (Aches) 08/01/2007 - "This study used the metabotropic glutamate 5 (mGlu5) receptor subtype-selective antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) to characterise the contribution of mGlu5 receptor activity to pain and hypersensitivity in an animal model of post-surgical pain. " 04/01/2005 - "The mGluR5 antagonists, 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP), and the mGluR1 antagonist, (4-methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine HCl (LY456236), were tested in models of pain [mouse formalin test, rat spinal nerve ligation (SNL)] and anxiety [Vogel conflict, conditioned lick suppression (CLS)], and their efficacious effects were compared to any associated side effects. "
5.	Dyskinesias (Dyskinesia) 03/01/2013 - "This study sought to prevent the development of l-DOPA-induced dyskinesias (LID) with the metabotropic glutamate receptor type 5 (mGlu5 receptor) antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) in the de novo treatment of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a PD model. "

Related Drugs and Biologics

1.	metabotropic glutamate receptor type 1
2.	pyridine
3.	Glutamic Acid (Glutamate)
4.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
5.	Anticonvulsants (Antiepileptic Drugs)
6.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
7.	Morphine (MS Contin)
8.	Levodopa (L Dopa)
9.	Esters
10.	Oxcarbazepine (Trileptal)

Related Therapies and Procedures

1.	Ligation
2.	Induced Hyperthermia (Thermotherapy)