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KB R6933
structure in first source
Also Known As:
6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole dimaleate; KB-R6933
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
KB R6933: 3
Related Diseases
1.
Vomiting
09/01/1999 - "
KB-R6933 immediately inhibited the subsequent emesis when administered to the ferrets which exhibited established vomiting after administration of cisplatin.
"
09/01/1999 - "
The effects of a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, KB-R6933, 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate, on emesis and delayed gastric emptying induced by cisplatin were assessed in experimental models.
"
09/01/1999 - "
Improvement of cisplatin-induced emesis and delayed gastric emptying by KB-R6933, a novel 5-HT3 receptor antagonist.
"
2.
Diarrhea
05/01/1999 - "
The results suggest the possibility that KB-R6933 may have clinical efficacy in the treatment of diarrhea.
"
05/01/1999 - "
Effect of the 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 on experimental diarrhea models.
"
05/01/1999 - "
The effects of a 5-hydroxytryptamine3 (5-HT3)-receptor antagonist KB-R6933 (6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)-benzimidazole dimaleate) on experimental diarrhea and on intestinal fluid secretion stimulated by cholera toxin were examined and compared with those of ramosetron and loperamide.
"
05/01/1999 - "
KB-R6933 and ramosetron (0.03-1 mg/kg, p.o.) inhibited the diarrhea induced by 5-HT, but not that by castor oil or prostaglandin E2 (PGE2), in mice.
"
3.
Bradycardia
05/01/1999 - "
The inhibitory effect of KB-R6933 at a dose of 0.3 microg/kg lasted for at least 8 hr, whereas those of granisetron at 30 microg/kg, ondansetron at 100 microg/kg and azasetron at 30 microg/kg nearly disappeared within 2-4 hr. Oral administration of KB-R6933 and granisetron also inhibited the bradycardia, with ED50 values of 0.41 and 76.3 microg/kg, respectively.
"
05/01/1999 - "
Intravenous administration of KB-R6933, granisetron, ondansetron and azasetron inhibited 5-HT-induced bradycardia (von Bezold-Jarisch reflex) in anesthetized rats, with ED50 values of 0.071, 0.71, 4.0 and 0.82 microg/kg, respectively.
"
Related Drugs and Biologics
1.
5-HT3 Serotonin Receptors (5 HT3 Receptor)
2.
Granisetron (Kytril)
3.
Ondansetron (Zofran)
4.
Dinoprostone (PGE2)
5.
Serotonin (5 Hydroxytryptamine)
6.
Loperamide (Imodium)
7.
Cisplatin (Platino)
8.
Cholera Toxin
9.
Castor Oil (Oil, Castor)
10.
ramosetron (Nasea)
Related Therapies and Procedures
1.
Intravenous Administration
2.
Oral Administration