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5-fluorodeoxyuridine-dipalmitate

a prodrug able to deliver the active drug to colon carcinoma cells with high efficiency

Also Known As:

5-FUDR-dipalmitate; FUdR-dP

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kamps, Jan A A M: 1 article (01/2002)
2.	Koning, Gerben A: 1 article (01/2002)
3.	Scherphof, Gerrit L: 1 article (01/2002)
4.	Allen, T M: 1 article (09/2001)
5.	Gorter, A: 1 article (09/2001)
6.	Kamps, J A: 1 article (09/2001)
7.	Koning, G A: 1 article (09/2001)
8.	Morselt, H W: 1 article (09/2001)
9.	Scherphof, G L: 1 article (09/2001)
10.	Zalipsky, S: 1 article (09/2001)

Related Diseases

1.	Neoplasms (Cancer) 08/20/1999 - "Based on these observations, we tentatively conclude that during the interaction of the immunoliposomes with the tumor cells the lipophilic prodrug FUdR-dP is selectively transferred to the cell surface and subsequently internalized by constitutive endocytic or pinocytic invaginations of the plasma membrane, thus ultimately delivering the prodrug to a lysosomal compartment where hydrolysis and release of parent drug takes place. " 09/01/2001 - "Although with a long-circulating immunoliposome formulation, efficiently retaining the prodrug FUdR-dP, we achieved enhanced uptake by hepatic metastases, this was probably not mediated by specific interaction with the tumor cells, but rather by tumor-associated macrophages." 01/01/2002 - "A monoclonal antibody against the rat colon carcinoma CC531 was covalently coupled to liposomes containing a dipalmitoylated derivative of the anti-cancer drug FUdR (FUdR-dP) as a prodrug in their bilayers. "
2.	Neoplasm Metastasis (Metastasis) 09/01/2001 - "Although with a long-circulating immunoliposome formulation, efficiently retaining the prodrug FUdR-dP, we achieved enhanced uptake by hepatic metastases, this was probably not mediated by specific interaction with the tumor cells, but rather by tumor-associated macrophages."
3.	Colonic Neoplasms (Colon Cancer) 08/01/1999 - "Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells." 08/01/1999 - "We have investigated the antiproliferative action towards CC531 colon adenocarcinoma cells of target cell-specific immunoliposomes containing the amphiphilic dipalmitoyl derivative of 5-fluorodeoxyuridine (FUdR-dP). "
4.	Carcinoma (Carcinomatosis) 01/01/2002 - "A monoclonal antibody against the rat colon carcinoma CC531 was covalently coupled to liposomes containing a dipalmitoylated derivative of the anti-cancer drug FUdR (FUdR-dP) as a prodrug in their bilayers. "

Related Drugs and Biologics

1.	Prodrugs
2.	Floxuridine (FUdR)
3.	Liposomes (Liposome)
4.	Monoclonal Antibodies