adenylyl cyclase 6

amino acid sequence known

Also Known As:

AC6 adenylate cyclase; ADCY6 protein, human; Adcy6 protein, mouse; Adcy6 protein, rat; adenylate cyclase 6; adenylate cyclase 6, human; adenylate cyclase 6, mouse; adenylate cyclase 6, rat; adenylyl cyclase type VI; type VI adenylyl cyclase

Networked: 27 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Phosphorus-Oxygen Lyases
      - Adenylyl Cyclases: 3540
        adenylyl cyclase 6: 27
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Adenylyl Cyclases: 3540
      - adenylyl cyclase 6: 27

Experts

1.	Hammond, H Kirk: 11 articles (01/2016 - 04/2002)
2.	Gao, Mei Hua: 10 articles (01/2016 - 04/2002)
3.	Lai, N Chin: 6 articles (01/2016 - 07/2004)
4.	Tang, Tong: 6 articles (07/2013 - 07/2004)
5.	Guo, Tracy: 4 articles (07/2013 - 09/2004)
6.	Roth, David M: 4 articles (04/2010 - 04/2002)
7.	Fenton, Robert A: 2 articles (10/2019 - 01/2017)
8.	Rieg, Timo: 2 articles (10/2019 - 01/2017)
9.	Harris, Peter C: 2 articles (01/2017 - 01/2015)
10.	Kohan, Donald E: 2 articles (01/2017 - 02/2014)

Related Diseases

1.	Heart Failure 01/01/2016 - "To evaluate the safety and efficacy of intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 (Ad5.hAC6) in heart failure. " 10/01/2016 - "Many studies have already verified that Adenylyl Cyclase 6 (AC6) can ameliorate heart failure, but it is still unknown whether or not the pathway HSF1 is involved in the process. " 10/01/2006 - "The rationale for gene transfer of adenylyl cyclase type VI (AC(VI)) for clinical congestive heart failure (CHF) is based on recent experimental studies that have extended from cultured cardiac myocytes to preclinical studies in animal models of CHF. " 01/01/2016 - "Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial." 07/20/2004 - "We tested the hypothesis that intracoronary delivery of an adenovirus encoding adenylyl cyclase type VI (Ad.AC(VI)) would be associated with increased left ventricular (LV) function in pigs with congestive heart failure. "
2.	Cysts 10/01/2015 - "Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adenylate cyclase 6 (AC6). " 01/01/2015 - "Compounds such as tolvaptan and pasireotide, which indirectly reduce adenylyl cyclase 6 (AC6) activity, have hence proven effective in slowing cyst progression. "
3.	Polycystic Kidney Diseases (Polycystic Kidney Disease) 02/01/2014 - "Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease."
4.	Neoplasms (Cancer) 10/01/2023 - "Recently, studies have found that adenylate cyclase 6 (ADCY6) plays a pivotal role in many lethal tumors formation processes. " 09/07/2000 - "Northern blots using specific probes showed that the expression of adenylyl cyclase type VI gene was significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue, in one follicular cold adenoma or in one papillary carcinoma."
5.	Diarrhea 10/22/2019 - "We generated intestinal epithelial cell-specific adenylyl cyclase 6 (AC6) knockout mice to study its role in CT-induced diarrhea. " 10/22/2019 - "Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea."

Related Drugs and Biologics

1.	Tolvaptan
2.	pasireotide
3.	Calcium
4.	Proteins (Proteins, Gene)
5.	G-Protein-Coupled Receptor Kinase 2
6.	Protein Phosphatase 1
7.	phospholamban
8.	Adenylyl Cyclases (Adenylyl Cyclase)
9.	Messenger RNA (mRNA)
10.	Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1.	Therapeutics