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MEN 11467

a tachykinin NK1 receptor antagonist; structure in first source

Also Known As:

MED-11467

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Cyclohexylamines: 33
    - MEN 11467: 6
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexylamines: 33
        MEN 11467: 6
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - MEN 11467: 6

Experts

1.	Manzini, S: 2 articles (01/2001 - 01/2000)
2.	Büchler, Markus W: 1 article (05/2003)
3.	Friess, Helmut: 1 article (05/2003)
4.	Korc, Murray: 1 article (05/2003)
5.	Liard, Veronique: 1 article (05/2003)
6.	Lieb, Klaus: 1 article (05/2003)
7.	Palma, Carla: 1 article (05/2003)
8.	Reubi, Jean Claude: 1 article (05/2003)
9.	Shi, Xin: 1 article (05/2003)
10.	Shrikhande, Shailesh V: 1 article (05/2003)

Related Diseases

1.	Proctocolitis (Hemorrhagic Proctocolitis) 06/18/1999 - "Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs." 06/18/1999 - "The aim of this study was to evaluate the effect of MEN 11467 (1R,2S)-2-N[1(H)indol-3-yl-carbonyl]-1-N{N-(p-tolylacetyl)-N-(meth yl)-D-3(2-Naphthyl)alanyl}diaminocyclohexane), a new potent tachykinin NK1 receptor antagonist, in an experimental model of acute rectocolitis induced by an enema with 7.5% acetic acid in guinea-pigs. "
2.	Astrocytoma (Pilocytic Astrocytoma) 06/25/1999 - "Binding characteristics and functional antagonism exerted by two structurally related tachykinin NK1 receptor antagonists, MEN 11467 ((1R,2S)-2N[1(H)indol-3-yl-carbonyl]-1-N-{Nalpha(p-tolylacetyl+ ++)-Nalpha(methyl)-D-3-(2-naphthyl)alanyl}diaminocyclohexane) and FK888 (N2-[(4R)-4-hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methy l-N-phenylmethyl-L-3-(2-naphthyl)alaninamide), were investigated in the human astrocytoma cell line U373 MG. In radioligand binding studies, conducted with [3H]substance P and intact cells at 37 degrees C, MEN 11467 bound to tachykinin NK1 receptors in an irreversible manner with a Ki value of 1.2+/-0.5 nM while FK888 bound in competitive manner with a Ki value of 4.6+/-2.2 nM. Receptor blockade by both antagonists resulted in a powerful and complete inhibition of functional responses induced by substance P, such as accumulation of the second messenger inositol monophosphate or interleukin-6 release. "
3.	Glioma (Gliomas) 01/01/1999 - "All the stimulant effects of SP/NKA on NK1R+ glioma cell lines were completely blocked by a specific tachykinin NK1R antagonist, MEN 11467. " 01/01/2000 - "Although the administration of exogenous SP did not significantly affect the size or development of U373 MG xenograft, a role of SP in supporting glioma progression in vivo was highlighted by the tumour growth inhibition induced by highly specific and selective human tachykinin NK1 receptor antagonists (MEN 11467 and MEN 11149). "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 05/01/2003 - "Furthermore, the influence of SP analogs and of the NK-1R antagonist MEN 11467 on pancreatic cancer cell growth was analyzed by sulforhodamine B (SRB) assay. "
5.	Necrosis 06/18/1999 - "A single administration of MEN 11467 (0.3-10 mg/kg s.c., I h before acetic acid) reduced the macroscopic damage and necrosis score and the increase in plasma protein extravasation induced by 7.5% acetic acid in the early acute phase of the injury (death at 2.5 h). "

Related Drugs and Biologics

1.	Tachykinins
2.	Acetic Acid (Vinegar)
3.	Interleukin-6 (Interleukin 6)
4.	Substance P
5.	Inositol (Myoinositol)
6.	FK 888
7.	Blood Proteins (Serum Proteins)
8.	MEN 11149
9.	lissamine rhodamine B (sulforhodamine B)

Related Therapies and Procedures

1.	Enema (Enemas)