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methylserine phosphate (MSOP)

mGLuR antagonist

Also Known As:

MSOP; (RS)-alpha-methylserine-O-phosphate; alpha-MSOP

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Neutral Amino Acids: 200
    - Serine: 6037
      - Phosphoserine: 111
        methylserine phosphate: 4
  - Phosphoamino Acids: 1
    - Phosphoserine: 111
      - methylserine phosphate: 4

Experts

1.	Bandini, Marco: 1 article (03/2020)
2.	Briganti, Alberto: 1 article (03/2020)
3.	Graefen, Markus: 1 article (03/2020)
4.	Karakiewicz, Pierre I: 1 article (03/2020)
5.	Marchioni, Michele: 1 article (03/2020)
6.	Montorsi, Francesco: 1 article (03/2020)
7.	Nazzani, Sebastiano: 1 article (03/2020)
8.	Preisser, Felix: 1 article (03/2020)
9.	Saad, Fred: 1 article (03/2020)
10.	Schips, Luigi: 1 article (03/2020)

Related Diseases

1.	Seizures (Absence Seizure) 07/20/2001 - "Another Group III agonist, (RS)-4-phosphonophenyl-glycine (PPG), preferentially activating the mGlu(8) receptor, previously shown to protect against sound-induced seizures in DBA/2 mice and GEP rats, also protects against seizures induced in DBA/2 by 3,5-DHPG (ED(50) 3.7 [2.4-5.7], nmol i.c.v.) and by the Group III antagonist, MSOP (ED(50) 40.2 [21.0-77.0], nmol i.c.v.). " 07/20/2001 - "In contrast, the anticonvulsant protection against sound-induced seizures in DBA/2 mice provided by a fully protective dose (20 nmol, i.c.v.) of the mGlu(8) receptor agonist PPG, is not significantly affected by the co-administration of the same Group III antagonists, MSOP, MPPG or MAP4. " 07/20/2001 - "ACPT-1 also protects against clonic seizures induced in DBA/2 mice by the Group I agonist, (RS)-3,5-dihydroxyphenylglycine (3,5-DHPG) (ED(50) 0.60 [0.29-1.2], nmol i.c.v.) and by the Group III antagonist, (RS)-alpha-methylserine-O-phosphate (MSOP) (ED(50) 49.3 [37.9-64.1], nmol i.c.v.). " 07/20/2001 - "The anticonvulsant protection against sound-induced seizures in DBA/2 mice provided by a fully protective dose (20 nmol, i.c.v.) of the mGlu(4) receptor agonist ACPT-1, is partially reversed by the co-administration of the Group III antagonists, MSOP, (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) or (S)-2-amino-2-methyl-4-phosphonobutanoic acid (MAP4), in the 20-50 nmol dose range. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2019 - "We further confirmed that the activation of mGluR4 by VU0155041, an mGluR4-specific agonist, decreased cyclic adenosine monophosphate (cAMP) concentration and cell viability, promoted apoptosis and inhibited proliferation in bladder cancer cells, whereas MSOP (group III mGluR antagonist) or mGluR4 knockdown eliminated the effects of mGluR4 activity. " 01/01/2019 - "Western blotting revealed the decreased cyclin D1 expression, increased procaspase-8/9/3 cleavage, and unbalanced Bcl-2/Bax expression in bladder cancer cell lines after mGluR4 activation, and likewise MSOP and mGluR4 knockdown abrogated the actions of mGluR4 activity. "
3.	Pain (Aches) 02/01/2007 - "Intra-lateral PAG (S)-3,4-DCPG reduced pain behaviour when administered 10 min before formalin or carrageenan; both the effects were blocked by intra-lateral PAG MSOP. " 02/01/2007 - "When microinjected into the lateral PAG (RS)-alpha-methylserine-O-phoshate (MSOP), a group III receptor antagonist, antagonised the analgesic effect induced by systemic administration of (S)-3,4-DCPG in both of the inflammatory pain models. "
4.	Delirium 03/01/2020 - "No contemporary population-based assessments of delirium after MSOP have been reported. " 03/01/2020 - "According to our findings, delirium after MSOP has a profound impact on patient outcomes that ranges from prolonged length of stay to higher mortality and increased in-hospital charges." 03/01/2020 - "Delirium after MSOP was associated with prolonged length of stay (OR 3.00), higher mortality (OR 1.15), and increased in-hospital charges (OR 1.13). "

Related Drugs and Biologics

1.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Adenosine Monophosphate (AMP)
4.	Acids
5.	VU 0155041
6.	1-aminocyclopentane-1,2,4-tricarboxylic acid
7.	metabotropic glutamate receptor 4
8.	methylserine phosphate (MSOP)
9.	Caspase 8 (Caspase-8)
10.	Cyclin D1

Related Therapies and Procedures

1.	Length of Stay