TRPV6 channel

a calcium transport protein; a marker for prostate cancer progression; RefSeq NM_053686 (rat)

Also Known As:

CaT1 calcium channel; CaT1 protein, rat; Trpv6 protein, rat; transient receptor potential cation channel, subfamily V, member 6 protein, rat

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Transient Receptor Potential Channels: 706
        TRPV Cation Channels: 406
        TRPV6 channel: 11

Experts

1.	Cai, Ruiqi: 1 article (01/2021)
2.	Chen, Xing-Zhen: 1 article (01/2021)
3.	Kim, Duk Yoon: 1 article (01/2021)
4.	Kim, Soon Hee: 1 article (01/2021)
5.	Liu, Xiong: 1 article (01/2021)
6.	Michalak, Marek: 1 article (01/2021)
7.	Peng, Ji-Bin: 1 article (01/2021)
8.	Tang, Jingfeng: 1 article (01/2021)
9.	Wang, Lingyun: 1 article (01/2021)
10.	Yang, Eun Kyoung: 1 article (01/2021)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 08/01/2013 - "Since extracellular calcium is a known inactivator of the TRPV6 channel, which is also involved in the colon cancer progression, the present study aims to determine a possible modulation by CPPs of the molecular structures responsible for paracellular and/or transcellular calcium absorption in these two cell lines. "
2.	Neoplasms (Cancer) 03/15/2012 - "The role of the TRPV6 channel in cancer." 03/17/2023 - "The efforts to target the TRPV6 channel in vivo are still ongoing to propose an effective therapy against cancer. " 12/27/2022 - "Among them, only one antibody, rb79, was capable of detecting the full-length glycosylated form of the TRPV6 channel at around 100 kDa. The generated antibody was shown to be suitable for all in vitro applications, such as immunoblotting, immunoprecipitation, immunocytochemistry, immunofluorescence, etc. One of the most important applications is immunohistochemistry using the paraffin-embedded sections from cancer resection specimens. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "The transient receptor potential vanilloid 6 (TRPV6) channel is overexpressed in prostate cancer and its silencing is known to inhibit the growth of LNCaP cells. " 11/15/2007 - "TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways."
4.	Leukemia 09/27/2002 - "The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells." 05/01/2009 - "Moreover, we demonstrated that TRPV5 and TRPV6 channel proteins are present in both the total lysates and the crude membrane preparations from leukemia cells. " 09/27/2002 - "The activation mechanism of the recently cloned human transient receptor potential vanilloid type 6 (TRPV6) channel, originally termed Ca(2+) transporter-like protein and Ca(2+) transporter type 1, was investigated in whole-cell patch-clamp experiments using transiently transfected human embryonic kidney and rat basophilic leukemia cells. " 09/27/2002 - "Release of stored Ca(2+) by inositol 1,4,5-trisphosphate and/or the sarco/endoplasmic reticulum Ca(2+)-ATPase inhibitor thapsigargin appears not to be involved in TRPV6 channel gating in both cell lines but, in rat basophilic leukemia cells, readily activates the endogenous Ca(2+) release-activated Ca(2+) current. "
5.	Dysbiosis 01/01/2023 - "Here we explored the involvement of the TRPV6 channel in stress (or corticosterone) 3and alcohol-induced intestinal epithelial permeability, microbiota dysbiosis, and systemic inflammation. "

Related Drugs and Biologics

1.	Calcium
2.	Proteins (Proteins, Gene)
3.	Thapsigargin
4.	Inositol 1,4,5-Trisphosphate
5.	Paraffin
6.	Corticosterone
7.	Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1.	Therapeutics