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mitochondrial permeability transition pore

Mitochondrial permeability transition pores is a function describing leaky mitochondria without known structure; one model proposed is being an aggregation of misfolded membrane proteins (possibly including cyclophilin D from the matrix, the adenine nucleotide translocator from the inner membrane, the voltage-dependent anion channel from the outer membrane and others including creatine kinase in the intermembrane space, hexokinase at the outer surface of the outer membrane, the peripheral benzodiazepine receptor, and Bax protein [He, FEBS Let 512:1 2002 PMID: 11852041].
Also Known As:
cyclosporin A-SPTP; cyclosporin A-sensitive pereability transition pore; mPTP protein; mitochondrial megachannel (MMC); permeability transition pore, mitochondrial
Networked: 395 relevant articles (13 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ovize, Michel: 19 articles (12/2015 - 01/2005)
2. Yellon, Derek M: 15 articles (10/2014 - 12/2003)
3. Xia, Qiang: 11 articles (03/2014 - 01/2005)
4. Hausenloy, Derek J: 10 articles (01/2015 - 12/2003)
5. Davidson, Sean M: 10 articles (10/2014 - 03/2006)
6. Gao, Qin: 9 articles (11/2010 - 01/2005)
7. Sahach, V F: 9 articles (01/2008 - 01/2002)
8. Molkentin, Jeffery D: 8 articles (05/2015 - 09/2007)
9. Bernardi, Paolo: 7 articles (07/2015 - 05/2007)
10. Argaud, Laurent: 6 articles (10/2014 - 01/2005)

Related Diseases

1. Ischemia
2. Reperfusion Injury
3. Myocardial Ischemia (Ischemic Heart Diseases)
4. Neoplasms (Cancer)
5. Hypothermia

Related Drugs and Biologics

1. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
2. Adenosine Triphosphate (ATP)
3. Atractyloside
4. 5-hydroxydecanoic acid
5. Cyclosporine (Ciclosporin)
6. Phosphotransferases (Kinase)
7. Potassium Channels (Potassium Channel)
8. Leptin
9. cyclophilin D
10. Calcineurin

Related Therapies and Procedures

1. Ischemic Postconditioning
2. Induced Heart Arrest (Cardioplegia)
3. Vagus Nerve Stimulation
4. Resuscitation
5. Intraperitoneal Injections