BP 897

a dopamine D3 receptor agonist; structure in first source

Also Known As:

2-naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-, hydrochloride (1:1); BP-897; 2-naphthalenecarboxamide, N-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - BP 897: 7

Experts

1.	Perachon, S: 2 articles (10/2001 - 01/2000)
2.	Schwartz, J C: 2 articles (10/2001 - 01/2000)
3.	Sokoloff, P: 2 articles (10/2001 - 01/2000)
4.	Beninger, Richard J: 1 article (01/2008)
5.	Beuk, Jonathan: 1 article (01/2008)
6.	Heidbreder, Christian A: 1 article (01/2008)
7.	Swain, Shelley N: 1 article (01/2008)
8.	Preti, Antonio: 1 article (06/2007)
9.	Gyertyán, István: 1 article (05/2005)
10.	Laszlovszky, István: 1 article (05/2005)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 10/01/2001 - "As drug-associated cues maintain drug-seeking in animals and elicit craving and relapse in humans, D3R agents like BP 897 may represent new medications for drug addiction, with minimal liability to maintaining dependence." 07/20/2001 - "N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]naphthalene-2-carboxamide (BP 897) is a dopamine D3 receptor selective ligand recently described as partial agonist with potential effects on drug-dependence. "
2.	Dyskinesias (Dyskinesia) 01/01/2003 - "Although BP 897 reduces L-DOPA-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, it provokes a return of parkinsonian symptoms. "
3.	Cocaine-Related Disorders (Cocaine Addiction) 01/01/2003 - "These interesting preclinical findings with BP 897 provide additional validation for dopamine D(3) receptor as a therapeutic target for the treatment of cocaine abuse and its associated central nervous system (CNS) disorders. " 01/01/2003 - "BP 897 is a potent (K(i) = 0.92 nM) dopamine D(3) receptor compound developed for the treatment of cocaine abuse and craving. " 01/01/2003 - "BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction."
4.	Shock 01/28/2008 - "Injections of BP 897 (1.0, 2.0 mg/kg) or SB-277011A (10.0 mg/kg) prior to conditioned stimulus-shock pairings did not significantly affect subsequent response suppression. "
5.	Schizophrenia (Dementia Praecox) 06/01/2007 - "On the basis of the known neurochemistry of cocaine, some target compounds have been studied: among others, BP-897, a D3 partial agonist; vanoxerine, a highly selective inhibitor of dopamine uptake; aripiprazole, a partial mixed-action agonist approved for the treatment of schizophrenia. "

Related Drugs and Biologics

1.	Dopamine D3 Receptors
2.	Ligands
3.	Dopamine (Intropin)
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	Scopolamine (Hyoscine)
6.	Levodopa (L Dopa)
7.	Cocaine (Cocaine HCl)
8.	Aripiprazole (Abilify)
9.	vanoxerine (I 893)
10.	naphthalene

Related Therapies and Procedures

1.	Injections
2.	Induced Hypothermia