sortase A

09/10/2021 - "The exemplary BiFabs against different targets showed superior efficacy in redirecting and activating T cells to specifically kill target tumor cells, demonstrating the robustness of sortase A-mediated "bio-click" chemistry in generating various potent BiFabs. "
01/01/2023 - "Compound 2 displayed significant cytotoxicity against various cancer cell lines (IC50 = 1.58 μM against HCT116), whereas 3 showed inhibitory activity against Staphylococcus aureus sortase A. "
01/17/2022 - "The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A-C were investigated."
11/01/2020 - "MY1523 was radiolabeled with 99mTc by a site-specific transpeptidation of Sortase-A, and the biodistribution and single photon emission CT (SPECT)/CT were performed in mice bearing different tumors. "
09/10/2021 - "Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy."

12/01/2021 - "Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A."
12/01/2022 - "Cyanidin chloride protects mice from methicillin-resistant Staphylococcus aureus-induced pneumonia by targeting Sortase A."
11/21/2022 - "The protection effect of rhodionin against methicillin-resistant Staphylococcus aureus-induced pneumonia through sortase A inhibition."
10/28/2022 - "Isovitexin Protects Mice from Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia by Targeting Sortase A."
01/01/2021 - "Eriodictyol as a Potential Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia."

05/21/2012 - "Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A."

01/01/2021 - "Sortase A (SrtA) inhibitors as an alternative treatment for superbug infections."
01/01/2015 - "Sortase A (SrtA) has attracted great interest as a potential drug target to treat infections caused by S. "
05/28/2010 - "The rate of kidney infection was significantly reduced in the mice treated with sortase A knock-out S. "
10/23/2017 - "Three natural compounds were identified in this study as promising candidates for further development into therapeutically useful anti-infective agents that could be used to treat infections caused by multi-drug resistant bacterial pathogens which include sortase A in their enzymatic set."
01/01/2022 - "Punicalagin, an Inhibitor of Sortase A, Is a Promising Therapeutic Drug to Combat Methicillin-Resistant Staphylococcus aureus Infections."

01/01/2016 - "Chinese herb medicine against Sortase A catalyzed transformations, a key role in gram-positive bacterial infection progress."
11/06/2023 - "Here, we describe a method for targeting Gram-positive bacterial infection by combining curcumin and trans-chalcone as sortase A inhibitors. "
11/06/2023 - "Harnessing the combined effect of antivirulence agent trans-chalcone with bactericidal curcumin against sortase A enzyme to tackle Gram-positive bacterial infections."
10/01/2014 - "Sortase A (srtA) is the key enzyme that anchors pre-mature cell wall-attached proteins to peptidoglycan and it can affect the correct positioning of surface proteins, as well as the course of Gram-positive bacterial infection, thereby making it a potential target in the study of virulence factors and disease control. "