HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

4N1K peptide

CD47 agonist peptide, derived from the CBD, synergizes with soluble collagen in aggregating platelet-rich plasma

Also Known As:

4N1K; KRFYVVMWKK

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - 4N1K peptide: 8

Experts

1.	Miyata, Yasuyoshi: 3 articles (05/2019 - 05/2003)
2.	Sakai, Hideki: 2 articles (05/2019 - 08/2012)
3.	Kanetake, Hiroshi: 2 articles (08/2012 - 05/2003)
4.	Bao, Xiaoyan: 1 article (07/2022)
5.	Dai, Qi: 1 article (07/2022)
6.	Han, Min: 1 article (07/2022)
7.	Ke, Peng: 1 article (07/2022)
8.	Liang, Min: 1 article (07/2022)
9.	Lu, Yiying: 1 article (07/2022)
10.	Wang, Tiantian: 1 article (07/2022)

Related Diseases

1.	Inflammation (Inflammations) 09/01/2015 - "Furthermore, a TSP-1-derived peptide, 4N1K, exhibited significant antimicrobial activity when compared to a control peptide against commensal sp. These studies illustrate that alterations in the commensal frequency occur in the early stages of development of Sjögren's-like pathology and suggest that interventions that limit commensal outgrowth such as the use of TSP-1-derived peptides could be used for treatment during the early stages of the disease to reduce the commensal burden and ensuing inflammation."
2.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2019 - "TSP-2 and 4N1K peptide played important roles in malignant aggressiveness and progression of bladder cancer via complex mechanisms involving cell proliferation, apoptosis, angiogenesis, and MMP-9." 05/01/2019 - "The aim of the study was to evaluate the pathological significance and prognostic role of the 4N1K-peptide (KRFYVVMWKK), which is derived from TSP-1 and -2, in bladder cancer. "
3.	Neoplasms (Cancer) 08/28/2012 - "4N1K expression appears to be associated with cancer cell progression and survival in UC-UUT patients via the regulation of angiogenesis, apoptosis, and MMP-9 expression. " 08/28/2012 - "Of the 97 specimens, 45 patients were positive for 4N1K expression, which was primarily located in the interstitial areas of the cancer tissue. " 07/26/2022 - "Inspired by the phenomenon of molecular self-assembly, we modify the CD47 targeting peptide (4N1K) onto the self-assembled peptide FY4, as well as the concatenation of PEG at the other terminal via the AZO group to construct hypoxia-responsive nanoparticles (PEG-AZO-FY4-4N1K, PAP NPs), utilizing the peptide as a part of the anti-tumor therapy machine. " 05/01/2003 - "Expression of thrombospondin-derived 4N1K peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis."
4.	Melanoma (Melanoma, Malignant) 08/26/2003 - "Melanoma cell spreading on vitronectin was strongly stimulated by immobilized rCBD co-coated at concentrations more than 50x lower than 4N1K, and the effect was blocked by treatment with pertussis toxin, consistent with the known mediation of CD47 signaling by trimeric G(i). " 08/26/2003 - "A recombinant form of the CBD (rCBD) has been expressed that contains both VVM sites and exhibits CD47-dependent binding of C32 melanoma cells when coated at concentrations 100x lower than the peptide 4N1K (kRFYVVMWKk). " 10/01/1996 - "Here we examine the effects of the TS1 CBD and 4N1K (KRFYVVMWKK), a cell-binding peptide derived from it, on the adhesion and spreading on vitronectin (VN) of C32 human melanoma cells which express IAP, alpha v beta 3, and alpha v beta 5. Cells adhere to VN at low surface densities via alpha v beta 5 and spread very slowly while adhesion to higher density VN involves both alpha v beta 5 and alpha v beta 3 and results in rapid spreading. "
5.	Neoplasm Metastasis (Metastasis) 08/28/2012 - "Survival analyses revealed that 4N1K is a predictor of metastasis-free (p = 0.036) and cause-specific survival (p = 0.009). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Thrombospondin 1
3.	4N1K peptide
4.	Vitronectin
5.	Pertussis Toxin
6.	Matrix Metalloproteinases (MMPs)
7.	Thrombospondins
8.	Proteins (Proteins, Gene)
9.	Ligands
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Therapeutics