|1.||Matsumoto, Kinzo: 10 articles (02/2015 - 06/2003)|
|2.||Zhao, Qi: 6 articles (01/2013 - 06/2003)|
|3.||Tohda, Michihisa: 6 articles (12/2007 - 06/2003)|
|4.||Murakami, Yukihisa: 6 articles (12/2007 - 06/2003)|
|5.||Watanabe, Hiroshi: 5 articles (10/2005 - 06/2003)|
|6.||Niu, Yimin: 4 articles (02/2015 - 01/2012)|
|7.||Shimada, Yutaka: 4 articles (12/2007 - 01/2003)|
|8.||Tanaka, Ken: 3 articles (02/2015 - 01/2012)|
|9.||Sasaki-Hamada, Sachie: 3 articles (02/2015 - 01/2013)|
|10.||Goto, Hirozo: 3 articles (12/2007 - 01/2003)|
|1.||Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
11/01/1999 - "These results suggest that Choto-san is effective in the treatment of vascular dementia. "
03/01/1997 - "These results suggest that Choto-san is effective in the treatment of vascular dementia."
11/01/1999 - "Two different multicenter studies on the efficacy of Choto-san on patients with vascular dementia, one a well-controlled but non-double blind (60 patients), the other a double-blind controlled study (139 patients), were performed. "
06/01/2003 - "To clarify the clinical efficacy of one of the traditional medicines in the treatment of patients with vascular dementia, we investigated the pharmacological activities of Choto-san in animal models. "
03/01/1997 - "Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study."
09/01/2004 - "Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil."
01/01/2003 - "The results of this study indicated that Choto-san prevents delayed neuronal cell death in the hippocampal CA1 region after ischemia. "
12/01/2004 - "Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia."
01/01/2003 - "Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine)."
01/01/2005 - "These results suggest that simultaneous induction of cellular antioxidant defense systems by Choto-sam and its related constituents may be an important mechanisms underlying the protective effects of Choto-san on ischemia-induced neuronal cells injury, and the characteristics of the stimulative effects of phenolic compounds were depend on enzymes."
12/01/2007 - "Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glioma cells."
12/01/2007 - "In this study, we investigated the effect of chotosan, an oriental medicine, which has been clinically demonstrated to be effective for the treatment of vascular dementia, on M-CSF gene expression in rats with permanent occlusion of bilateral common carotid arteries (P2VO) in vivo and in a C6Bu-1 glioma cell line in vitro. "
12/01/2007 - "Moreover, the present in vitro studies revealed that chotosan treatment (10-100 mug/ml) of C6Bu-1 glioma cells dose-dependently enhanced M-CSF mRNA expression without affecting the expression of G-CSF, GM-CSF, and inducible nitric oxide synthase mRNAs. "
|4.||Memory Disorders (Memory Loss)
03/01/1997 - "Such items as spontaneity of conversation, lack of facial expression, decline in simple mathematical ability, global intellectual ability, nocturnal delirium, sleep disturbance, hallucination or delusion, and putting on and taking off clothes were significantly improved at one or more evaluation points in those taking Choto-san compared to those taking the placebo. "
|2.||Macrophage Colony-Stimulating Factor
|3.||Glutamic Acid (Glutamate)
|5.||Messenger RNA (mRNA)
|6.||Nitric Oxide (Nitrogen Monoxide)
|7.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
|8.||Granulocyte Colony-Stimulating Factor (G-CSF)
|9.||Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
|1.||Kampo Medicine (Kampo)
|2.||East Asian Traditional Medicine (Oriental Medicine)
|3.||Traditional Medicine (Folk Remedies)
|4.||Activities of Daily Living (ADL)