|1.||Bretillon, Lionel: 5 articles (11/2012 - 04/2007)|
|2.||Acar, Niyazi: 5 articles (11/2012 - 04/2007)|
|3.||Björkhem, Ingemar: 4 articles (06/2015 - 04/2007)|
|4.||Bron, Alain: 4 articles (11/2012 - 04/2007)|
|5.||Creuzot-Garcher, Catherine: 4 articles (11/2012 - 04/2007)|
|6.||Fourgeux, Cynthia: 4 articles (11/2012 - 12/2009)|
|7.||Cartier, Nathalie: 3 articles (11/2015 - 01/2010)|
|8.||Moutinho, Miguel: 3 articles (06/2015 - 01/2010)|
|9.||Rodrigues, Elsa: 3 articles (06/2015 - 01/2010)|
|10.||Nunes, Maria João: 3 articles (06/2015 - 01/2010)|
|1.||Alzheimer Disease (Alzheimer's Disease)
02/07/2014 - "Genetically increased CYP46A1 expression in mice leads to improved cognition and decreases manifestations of Alzheimer disease. "
08/09/2013 - "CYP46A1 intron-2T/C polymorphism and Alzheimer's disease: an updated meta-analysis of 16 studies including 3,960 cases and 3,828 controls."
07/01/2013 - "Studies of the relationship between Alzheimer's disease (AD) and single nucleotide polymorphism (SNP) T/C in intron 2 of the cholesterol-24S-hydroxylase gene (CYP46A1) have reported inconsistent results. "
01/01/2003 - "In two further studies a polymorphism in the CYP46 gene encoding the cholesterol-24 hydroxylase was found to be associated with a significant increase in the risk of late-onset Alzheimer's disease. "
01/01/2003 - "To study the association of polymorphic sites on CYP46 with Alzheimer disease (AD) traits and with the risk of the development of AD. "
11/01/2012 - "In this context, the purpose of our present work was to emphasize the glial and longitudinal CYP46A1 expression after an interventional glaucoma-related stress triggered by elevated intraocular pressure (IOP). "
09/01/2011 - "Glaucoma is characterized by the loss of retinal ganglion cells, which show high CYP46A1 expression. "
09/01/2011 - "We recently published that one single nucleotide polymorphism in CYP46A1 gene, designated as rs754203, was a risk factor for glaucoma. "
11/01/2012 - "Our previous studies suggested that CYP46A1 and 24S-hydroxycholesterol (24SOH) may be associated with glaucoma. "
09/01/2011 - "These data suggest the potential involvement of CYP46A1 and 24S-hydroxycholesterol in the pathophysiology of glaucoma."
|4.||Brain Injuries (Brain Injury)
08/01/2010 - "The results of this study clearly demonstrate that in pathological conditions, like brain injury, Cyp46 displayed atypical expression, being expressed not only in neuronal cells, but also in microglia and astrocytes. "
08/01/2010 - "Since cholesterol homeostasis is disrupted following brain injury, in this study we examined the effect of right sensorimotor cortex suction ablation on cellular and temporal pattern of Cyp46 expression in the rat brain. "
08/01/2010 - "Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner."
01/01/2010 - "Our data demonstrate that neuronal overexpression of CYP46A1 before or after the onset of amyloid plaques significantly reduces Abeta pathology in mouse models of AD."
09/02/2004 - "Further, in an autopsy confirmed subset of this cohort, the proposed CYP46 risk genotype was not associated with any increase in the brain levels of amyloid-beta40, amyloid-beta42 or in the levels of amyloid plaques and neurofibrillary tangles. "
08/13/2004 - "The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP46A1 gene might influence the pathophysiology of this prevalent disease."
03/03/2009 - "Although amyloid plaque accumulation did not affect brain sterol or fatty acid synthesis rates in 24-hydroxylase WT or knockout mice, loss of one or both cholesterol 24-hydroxylase alleles increased longevity in Alzheimer's disease mice. "
08/13/2004 - "In Alzheimer's disease (AD), CYP46A1 shows prominent expression in astrocytes and around amyloid plaques, whereas CYP27A1 expression decreases in neurons and is not apparent around amyloid plaques but increases in oligodendrocytes. "
|1.||cholesterol 24-hydroxylase (CYP46)
|4.||Apolipoproteins E (ApoE)
|5.||Amyloid (Amyloid Fibrils)
|6.||tau Proteins (tau Protein)
|9.||Toll-Like Receptor 4