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SIB 1893

a selective mGluR5 antagonist; structure in first source

Also Known As:

(E)-2-methyl-6-(2-phenylethenyl)pyridine; SIB-1893; SIB1893

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - SIB 1893: 7

Experts

1.	Borowicz, Kinga K: 2 articles (11/2005 - 09/2003)
2.	Czuczwar, Stanisław J: 2 articles (11/2005 - 09/2003)
3.	Chen, Peng Min: 1 article (12/2007)
4.	Lee, Wei Ling: 1 article (12/2007)
5.	Tang, Feng Ru: 1 article (12/2007)
6.	Tang, Yong Cheng: 1 article (12/2007)
7.	Tsai, Mui Chiung: 1 article (12/2007)
8.	Ahn, Dong K: 1 article (11/2005)
9.	Bae, Yong C: 1 article (11/2005)
10.	Choi, Hyo S: 1 article (11/2005)

Related Diseases

1.	Hypothermia 11/01/2005 - "Based on our preclinical study, one can conclude that SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner."
2.	Parkinsonian Disorders (Parkinsonism) 01/28/2004 - "We combined the use of knock-out mice and subtype-selective antagonists [2-methyl-6-(phenylethynyl)pyridine (MPEP) and (E)-2-methyl-6-(2-phenylethenyl)-pyridine (SIB1893)] to examine whether endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the pathophysiology of nigro-striatal damage in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of parkinsonism. "
3.	Status Epilepticus (Complex Partial Status Epilepticus) 12/01/2007 - "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE). "
4.	Seizures (Absence Seizure) 07/10/2000 - "Sound-induced seizures in DBA/2 mice are suppressed at 15 min by MPEP and SIB 1893 (MPEP ED(50) clonic seizures=18 [10-32] mg/kg i.p., 93 [69-125] nmol i.c.v.; tonic seizures=6.1 [4.5-8.3] mg/kg i.p., 46 [26-80] nmol i.c.v.; SIB 1893 ED(50) clonic seizures=27 [17-44] mg/kg i.p., 825 [615-1108] nmol i. c.v., tonic seizures=5.4 [3.4-8.6] mg/kg i.p., 194 [113-332] nmol i. c.v.). " 07/10/2000 - "Clonic seizures induced by the selective mGlu5 agonist, (R,S)-2-chloro-5-hydroxyphenylglycine (CHPG), 3 micromol intracerebroventricularly (i.c.v.), are potently suppressed by both compounds (MPEP, ED(50)=0.42 [0.28-0.62] mg/kg intraperitoneally (i.p.); SIB 1893 ED(50)=0.19 [0.11-0.33] mg/kg i.p. " 07/10/2000 - "Clonic seizures induced by the mGlu1,5 agonist, 3, 5-dihydroxyphenylglycine (DHPG), 1.5 micromol i.c.v., are less potently suppressed by both compounds (MPEP, ED(50)=22 [13-38] mg/kg i.p., 110 [67-180] nmol i.c.v.; SIB1893, ED(50)=31 [18-54] mg/kg i.p. "
5.	Hyperalgesia 11/01/2005 - "Subcutaneous administration of CPCCOEt or LY367385, an mGluR1 antagonist, or MPEP or SIB1893, an mGluR5 antagonist, 10 min prior to injection of IL-1beta abolished IL-1beta-induced mechanical allodynia. "

Related Drugs and Biologics

1.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
2.	metabotropic glutamate receptor type 1
3.	alpha-methyl-4-carboxyphenylglycine
4.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
6.	Pilocarpine (Ocusert)
7.	Anticonvulsants (Antiepileptic Drugs)
8.	SIB 1757
9.	7- (hydroxyimino)cyclopropan(b)chromen- 1a- carbxoylic acid ethyl ester
10.	pyridine

Related Therapies and Procedures

1.	Intravenous Administration