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homocamptothecin

a DNA topoisomerase I antagonists, is a semisynthetic analogue of camptothecin (CPT) with a seven-membered beta-hydroxylactone resulting from the insertion of a mehthylene spacer between the alcohol moiety and the carboxyl function of the naturally occurring six-membered alpha-hydroxylactone of CPT; structure in first source
Also Known As:
hCPT
Networked: 142 relevant articles (16 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Li, Xiaohong: 6 articles (09/2015 - 05/2010)
2. Luo, Xiaoming: 6 articles (09/2015 - 05/2010)
3. Nie, Fang: 4 articles (01/2015 - 04/2011)
4. Xu, B: 4 articles (09/2001 - 04/2000)
5. Wang, Wei: 3 articles (07/2015 - 01/2011)
6. Yao, Yang: 3 articles (06/2014 - 08/2006)
7. Song, Haixing: 3 articles (01/2014 - 09/2012)
8. Xiao, Shu Dong: 3 articles (01/2012 - 04/2011)
9. Xu, Xi Tao: 3 articles (01/2012 - 04/2011)
10. Tong, Jin Lu: 3 articles (01/2012 - 04/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Urinary Bladder Neoplasms (Bladder Cancer)
3. Lung Neoplasms (Lung Cancer)
4. Hepatocellular Carcinoma (Hepatoma)
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Type I DNA Topoisomerases (Topoisomerase I)
2. Fluorouracil (Carac)
3. Genistein
4. Small Interfering RNA (siRNA)
5. P-Glycoprotein
6. Dimethyl Sulfoxide (DMSO)
7. Cyclophosphamide (Cytoxan)
8. 10-hydroxycamptothecin
9. Camptothecin
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Heterologous Transplantation (Xenotransplantation)
4. Aftercare (After-Treatment)
5. Laminectomy