homocamptothecin

a DNA topoisomerase I antagonists, is a semisynthetic analogue of camptothecin (CPT) with a seven-membered beta-hydroxylactone resulting from the insertion of a mehthylene spacer between the alcohol moiety and the carboxyl function of the naturally occurring six-membered alpha-hydroxylactone of CPT; structure in first source

Also Known As:

Networked: 274 relevant articles (32 outcomes, 75 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Jing: 8 articles (03/2021 - 01/2018)
2.	Li, Xiaohong: 7 articles (06/2016 - 05/2010)
3.	Luo, Xiaoming: 7 articles (06/2016 - 05/2010)
4.	Lei, Jiandu: 6 articles (01/2021 - 05/2018)
5.	Li, Xiaolei: 6 articles (01/2021 - 09/2015)
6.	Wang, Jingcheng: 6 articles (01/2021 - 09/2015)
7.	Wang, Wei: 6 articles (01/2021 - 01/2011)
8.	Sun, Yu: 6 articles (04/2019 - 09/2008)
9.	Ran, Haitao: 5 articles (01/2021 - 09/2012)
10.	Wang, Luying: 5 articles (01/2021 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2022 - "Furthermore, the formulation showed excellent anti-tumor activity in vitro and improved bioavailability of 3.4 times in vivo as comparing with free HCPT. " 11/01/2018 - "Moreover, the antitumor efficacy of HCPT/PEG45C18 NPs on 4T1-bearing mice was promoted significantly, the inhibition rate based on average tumor weight was 1.5-fold higher than HCPT/PEG45 NPs, besides, HCPT/PEG45C18 NPs exhibited better tumor accumulation than HCPT/PEG45 NPs. " 10/15/2013 - "Compared to commercial HCPT injection, in vivo experiments with HCPT nanosuspensions showed significantly increased HCPT concentrations in the blood and all tissues of the tested as well as improved tumor targetability and liver targetability. " 09/01/2001 - "Both forms of HCPT were effective against tumor growth, but C-HCPT was more effective than O-HCPT, the latter could be converted into the former under certain conditions." 01/01/2020 - "Tumor- bearing mouse models were used to assess the in vivo therapeutic efficacy of GA/TAT-HCPT-LP. "
2.	Lung Neoplasms (Lung Cancer) 12/01/2023 - "The combination of HCPT and CRI might be a promising therapeutic regimen and the conjugate CH-1was a potential target drug for the treatment of lung cancer." 05/01/2018 - "However, the involvement of autophagy in the antiproliferative effects of HCPT on lung cancer remains unclear. " 06/01/2011 - "We characterized the HCPT-loaded nanoparticles and determined their effects on lung cancer cell viability and apoptosis by using immunofluorescence light microscopy and SDS-PAGE/immunoblots. " 08/01/2008 - "These results suggest that PEG-NLCs is a promising delivery system for HCPT in the treatment of lung cancer." 04/01/2020 - "Here, we highlighted the AKT pathway as an important regulatory pathway for Arl4c expression in lung cancer cells and identified HCPT as a promising drug for lung adenocarcinoma treatment that functioned by targeting Arl4c expression."
3.	Urinary Bladder Neoplasms (Bladder Cancer) 12/01/2010 - "The efficacy of EPI and THP was significantly better than HCPT in the prevention of bladder cancer recurrence." 01/01/2020 - "The interaction between autophagy and apoptosis induced by HCPT and the molecular mechanism in bladder cancer cells were investigated in this study. " 08/01/2017 - "The present study demonstrated that Ad5-UPII-E1A combined with MMC or HCPT resulted in synergistic cytotoxicity in a process which involved the promotion of apoptosis in bladder cancer cell lines. " 01/01/2021 - "HNK in combination with HCPT produces a synergistic cell-killing effect on bladder cancer cells." 01/01/2020 - "Taken together, our findings showed that HCPT-induced autophagy mediated by the AMPK pathway in T24 and 5637 cell lines, which reinforced the apoptosis, indicating that HCPT together with autophagy activator would be a novel strategy for clinical treatment in bladder cancer."
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "HCPT@PT/PHF and HCPT@PT/PSF could enhance therapeutic efficacy of HCPT to colorectal cancer." 08/01/2006 - "47 patients with pathological evidence of recurrent and metastatic colorectal cancer were enrolled and treated with HCPT plus L-OHP regimen for 86 cycles. " 07/16/2015 - "The upregulated expression of RKIP in colorectal cancer cells inhibited cell invasion and metastasis, while downregulation of RKIP reduced chemosensitivity by inhibiting apoptosis induced by HCPT." 01/01/2019 - "The objective of this study was to deliver a ring-closed form of 10-hydroxycamptothecin (HCPT) to the mitochondria and nucleus to treat colorectal cancer. " 08/01/2006 - "This study was to evaluate the short-term effects and toxicity of combination of hydroxycamptothecine (HCPT) plus oxaliplatin (L-OHP) protocol in the treatment of recurrent and metastatic colorectal cancer. "
5.	Hepatocellular Carcinoma (Hepatoma) 07/01/1999 - "The results of this study suggest that the anti-hepatoma effect of HCPT may result from apoptosis induction and cell cycle disturbance." 01/01/2016 - "These results suggested that XG NLC/HCPT represent a promising carrier for drug delivery to the hepatoma and reverse the drug resistant of HepG2 cells and XG could be exploited as a potential targeting device for liver tissue. " 08/01/2006 - "Our results indicate that HCPT can inhibit proliferation and induce apoptosis of human hepatoma SMMC-7721 cells. " 07/01/1999 - "The results showed that HCPT inhibited proliferation of human hepatoma Hep G2, Bel-7402 and Bel-7404 cells at an optimal concentration of 0.1 microg/ml. This growth inhibition was dose and time dependent, and was accompanied by evidence of apoptotic changes and cell cycle perturbation in Hep G2 cells. " 01/01/2013 - "The results of this study show GL-BSA-HCPT to be a promising new vehicle for hepatocellular carcinoma-targeting therapy."

Related Drugs and Biologics

1.	hydroxycamptothecinum
2.	Solutions
3.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole
4.	Therapeutic Uses
5.	Type I DNA Topoisomerases (Topoisomerase I)
6.	Peptides (Polypeptides)
7.	Fluorouracil (Carac)
8.	Cytochromes c (Cytochrome c)
9.	Caspase 9
10.	Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Intravenous Injections
4.	Radiotherapy
5.	Therapeutics