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susalimod
analogue of sulphasalazine, was designed for use in the treatment of rheumatoid arthritis
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Sulfonamides: 2809
Sulfasalazine: 2747
susalimod: 2
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
susalimod: 2
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
susalimod: 2
Sulfur Compounds: 278
Sulfones: 534
Sulfonamides: 2809
Sulfasalazine: 2747
susalimod: 2
Related Diseases
1.
Fistula
09/01/1999 - "
From these results supported by a previous biliary excretion study in conscious dogs with chronic bile fistula receiving repeated administration of susalimod (Påhlman et al. 1999), it is likely that the hepatotoxic findings in dog are induced by the high concentrations of susalimod in the bile duct.
"
01/01/1999 - "
Efficient biliary excretion of susalimod, probably via the bromosulphthalein carrier, studied in a chronic bile fistula model in dogs.
"
2.
Hyperplasia
01/01/1999 - "
Susalimod is a structural analogue of sulphasalazine, known to be extensively excreted in the bile in various animal species and for inducing bile duct hyperplasia after long-term treatment of the dog with doses exceeding 25 mg kg(-1).
"
Related Drugs and Biologics
1.
Sulfobromophthalein (Sulfobromophthalein Sodium)
2.
Sulfasalazine (Azulfidine)