|1.||Shim, Jae-Hyuck: 2 articles (02/2008 - 11/2005)|
|2.||Ghosh, Sankar: 2 articles (02/2008 - 11/2005)|
|3.||Hammaker, Deepa R: 2 articles (01/2007 - 02/2004)|
|4.||Boyle, David L: 2 articles (01/2007 - 02/2004)|
|5.||Firestein, Gary S: 2 articles (01/2007 - 02/2004)|
|6.||Ma, Hong-chuang: 1 article (08/2015)|
|7.||Li, Hou-zhong: 1 article (08/2015)|
|8.||Wu, Yan: 1 article (08/2015)|
|9.||Yuan, Xiao-huan: 1 article (08/2015)|
|10.||Wang, Xue-yong: 1 article (08/2015)|
|1.||Prostatic Neoplasms (Prostate Cancer)
08/01/2010 - "In this study we report that TRAIL activates a TGF-beta-activated kinase 1 --> mitogen-activated protein kinase (MAPK) kinase 3 (MKK3)/MKK6 --> p38 pathway in prostate cancer cells that transcriptionally upregulates expression of the antiapoptotic BCL-2 family member MCL-1. "
02/01/2003 - "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3."
02/01/2003 - "Herein, we report that apoptosis of human prostate cancer PC-3U cells induced by TGF-beta1 or Smad7 overexpression is caused by a specific activation of the p38 mitogen-activated protein kinase pathway in a TGF-beta-activated kinase 1 (TAK1)- and mitogen-activated protein kinase kinase 3 (MKK3)-dependent manner. "
08/01/2010 - "Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis."
02/01/2004 - "RT-PCR studies of MAP3K gene expression in RA and osteoarthritis synovial tissue demonstrated mitogen-activated protein kinase/ERK kinase kinase (MEKK) 1, MEKK2, apoptosis-signal regulating kinase-1, TGF-beta activated kinase 1 (TAK1) gene expression while only trace amounts of MEKK3, MEKK4, and MLK3 mRNA were detected. "
05/01/2010 - "In this study, we used immunoblotting and immune complex kinase assays to provide evidence that the kinases thousand-and-one amino acid kinase 2 (TAO2) and transforming growth factor-beta-activated kinase 1 (TAK1) are rapidly activated in response to treatment of acute leukemia cells with As(2)O(3). "
09/01/2010 - "RANKL facilitated the formation of signaling complexes of tumour necrosis factor receptor-associated factor 6 and transforming growth factor beta-activated kinase 1 (TRAF6-TAK1), important for osteoclastogenesis and formation of such signalling complexes was prevented by 2-MS. "
02/01/2008 - "The protein kinase TAK1 (transforming growth factor-beta-activated kinase 1), which has been implicated in the activation of MAPK (mitogen-activated protein kinase) cascades and the production of inflammatory mediators by LPS (lipopolysaccharide), IL-1 (interleukin 1) and TNF (tumour necrosis factor), comprises the catalytic subunit complexed to the regulatory subunits, termed TAB (TAK1-binding subunit) 1 and either TAB2 or TAB3. "
12/16/2005 - "Transforming growth factor-beta (TGF-beta)-activated kinase 1 (TAK1) is a member of the MAPKKK family of protein kinases, and is involved in intracellular signalling pathways stimulated by transforming growth factor beta, interleukin-1 and tumour necrosis factor-alpha. "
04/01/2012 - "In the future, targeting nonredundant cytosolic mediators of the activation of NF-κB - such as TNF receptor associated factor family member-associated NF-κB activator -binding kinase 1 (TBK1) and TGF-beta activated kinase 1 (TAK1) - could represent a better approach to inhibit key processes in pancreatic tumor cells and make a difference for this devastating disease."
07/03/2009 - "We show here that, for wound healing, transforming growth factor-beta-activated kinase 1 (TAK1) in keratinocytes activates von Hippel-Lindau tumor suppressor expression, which in turn represses the expression of platelet-derived growth factor-B (PDGF-B), integrin beta1, and integrin beta5 via inhibition of the Sp1-mediated signaling pathway in the keratinocytes. "
|2.||Protein Kinases (Protein Kinase)
|3.||Messenger RNA (mRNA)
|4.||Antigen-Antibody Complex (Immune Complex)
|5.||Aligeron (AS 2)
|6.||Transforming Growth Factor beta (TGF-beta)
|7.||NF-kappa B (NF-kB)
|8.||Interleukin-1 (Interleukin 1)
|9.||Transforming Growth Factor beta1 (TGF beta 1)
|10.||Activating Transcription Factor 2