HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
GV 196771A
structure in first source
Also Known As:
E-4,6-dicholo-3(2-oxo-1-phenyl-pyrrolidin-3-glydenemethyl)-1H-indole-2-carboxylic acid; GV196771A
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Pyrroles: 369
GV 196771A: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
GV 196771A: 3
Experts
1.
Quartaroli, M
: 2 articles (11/2001 - 02/2000)
2.
Bettelini, L
: 1 article (11/2001)
3.
Corsi, M
: 1 article (11/2001)
4.
Fasdelli, N
: 1 article (11/2001)
5.
Maraia, G
: 1 article (11/2001)
6.
Bordi, F
: 1 article (02/2000)
Related Diseases
1.
Mononeuropathies (Mononeuritis Multiplex)
02/01/2000 - "
In the present study, we examined the effect of an NMDA-glycine site antagonist, GV196771A [E-4, 6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-ylidenemethyl)-1H- indole-2- carboxylic acid sodium salt], on responses to noxious stimuli both in normal rats and during peripheral mononeuropathy induced by chronic constriction injury (CCI) of the sciatic nerve.
"
2.
Hyperalgesia
07/01/1999 - "
Moreover, GV196771A (1-10 mg/kg p.o.) reversed the hyperalgesia when tested after the establishment of the CCI-induced hyperalgesia.
"
11/02/2001 - "
GV196771A (0.3-10 mg/kg, p.o.) dose-dependently inhibited established mechanical allodynia when tested 14 or 21 days after nerve ligation.
"
07/01/1999 - "
In the CCI model GV196771A (3 mg/kg twice a day p.o.), administered before and then for 10 days after nerve ligature, blocked the development of thermal hyperalgesia.
"
11/02/2001 - "
GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.
"
11/02/2001 - "
The effects of the N-methyl-D-aspartate (NMDA) receptor/glycine site antagonist, GV196771A (E-4,6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-ylidenemethyl)-1H-indole-2-carboxylic acid sodium salt), on mechanical allodynia and on tolerance to the antinociceptive effects induced by morphine were evaluated.
"
3.
Pain (Aches)
11/02/2001 - "
Moreover, the capability to strongly reduce morphine-induced tolerance suggests that GV196771A could be an alternative agent for the treatment of difficult pain states not only when given alone, but also in combination, in order to prolong the analgesic effects of the opiates.
"
4.
Neuralgia (Stump Neuralgia)
02/01/2000 - "
GV196771A and glycine antagonists in general may represent innovative and safe agents for the treatment of neuropathic pain.
"
Related Drugs and Biologics
1.
N-Methylaspartate (NMDA)
2.
Glycine (Aminoacetic Acid)
3.
Sodium
4.
Salts
5.
Carboxylic Acids
6.
Opiate Alkaloids
7.
N-Methyl-D-Aspartate Receptors (NMDA Receptors)
8.
Morphine (MS Contin)
9.
Analgesics (Analgesic Drugs)
Related Therapies and Procedures
1.
Ligation