gosha-jinki-gan

a Kampo medicine; composed of Rehmanniae radix, Achyranthis radix, Corni fructus, Dioscorea rhizoma, Plantaginis semen, Alismatis rhizoma, Hoelen, Moutan cortex, Cinnamoni cortex, Aconiti Calefactum tuber in ratio 5:3:3:3:3:3:3:3:1:1 mixed with 19 parts lactose

Also Known As:

Networked: 75 relevant articles (20 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kono, Toru: 10 articles (10/2021 - 08/2007)
2.	Mizuno, Keita: 4 articles (12/2021 - 01/2014)
3.	Sato, Yuzo: 4 articles (02/2010 - 02/2003)
4.	Mishima, Hideyuki: 3 articles (10/2021 - 12/2009)
5.	Morita, Satoshi: 3 articles (10/2021 - 12/2009)
6.	Sakamoto, Junichi: 3 articles (10/2021 - 12/2009)
7.	Kase, Yoshio: 3 articles (11/2016 - 01/2014)
8.	Omiya, Yuji: 3 articles (11/2016 - 01/2014)
9.	Andoh, Tsugunobu: 3 articles (07/2016 - 01/2013)
10.	Kuraishi, Yasushi: 3 articles (07/2016 - 01/2013)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 02/01/2003 - "Gosha-jinki-gan (GJG) is a Chinese herbal medicine that is known to be useful for the treatment of diabetic neuropathy. " 02/01/1999 - "Gosha-jinki-gan was considered useful for treating painful diabetic neuropathy." 12/16/1994 - "These observations confirm that Goshajinkigan relieves subjective symptoms and demonstrate that it improves vibration sensation in patients with diabetic neuropathy." 12/16/1994 - "Goshajinkigan, a herbal medicine, has long been used in Japan to alleviate the subjective symptoms of diabetic neuropathy; however, its effects have not been confirmed objectively. " 12/16/1994 - "The effects of goshajinkigan, a herbal medicine, on subjective symptoms and vibratory threshold in patients with diabetic neuropathy."
2.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2009 - "We have also found that Gosya-jinki-gan was possibly effective for the treatment and the prevention of peripheral neuropathy. " 01/01/2013 - "The effect of Goshajinkigan on peripheral neuropathy in the Goshajinkigan group was curative, effective, stabilizing, and deleterious in 3.4, 20.7, 69.0, and 6.9% of patients, compared to the effect in the non-Goshajinkigan group (4.5, 15.9, 45.5, and 34.1%). " 01/01/2012 - "This suggests that Goshajinkigan inhibits the progression of peripheral neuropathy." 01/01/2009 - "Recently, it has been reported that Gosya-jinki-gan is useful for the PTX induced peripheral neuropathy, so we carried a retrospective study(n=82)to evaluate the effectiveness of Gosya-jinkigan with the medical records. " 01/01/2009 - "Additionally Gosya-jinki-gan might be more effective for peripheral neuropathy when it is administered from the beginning of chemotherapy including PTX."
3.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2013 - "We aimed to determine whether treatment with goshajinkigan (TJ-107), a traditional Japanese medicine, is better than placebo in preventing OPN in patients with advanced or recurrent colorectal cancer patients treated with standard FOLFOX regimens. " 12/01/2009 - "We conducted a controlled double-blind randomized study in patients with advanced/recurrent colorectal cancer to investigate the efficacy of Goshajinkigan (GJG) for peripheral neurotoxicity induced by FOLFOX therapy. " 01/01/2011 - "Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer." 08/01/2011 - "The Kampo medicine, Goshajinkigan, is useful in preventing neuropathy in non-resectable or recurrent colorectal cancer patients treated with a FOLFOX regimen." 05/01/2008 - "We decided to use Gosha-jinki-gan for prevention of oxaliplatin-related neurotoxicity following the report of Fushiki et al. The subjects were 14 patients with metastatic colorectal cancer. "
4.	Neoplasms (Cancer) 03/03/2020 - "Recently, we demonstrated that Gosha-jinki-gan, a traditional Japanese medicine, completely reversed the spermatogenesis defects caused by cancer treatment in mice. " 05/01/2017 - "This systematic review will assess the efficacy and safety of Goshajinkigan for reducing CIPN in cancer patients receiving chemotherapy. " 01/01/2013 - "Paclitaxel (10 and 20 mg/kg, intraperitoneal, alternate day from day 7 postinoculation) inhibited the tumor growth, and Goshajinkigan (1 g/kg, oral, daily from day 2 postinoculation) did not affect the antitumor action of paclitaxel. " 10/01/2021 - "The aim of the present study was to evaluate the efficacy of TJ-107 for oxaliplatin-induced peripheral neurotoxicity in prospective, multi-institutional, randomized, double-blind, placebo-controlled Phase II trials using the functional assessment of cancer therapy/gynecologic oncology group 12-item neurotoxicity questionnaire (FACT-GOG-NTX-12). " 10/01/2021 - "Effects of Goshajinkigan (TJ-107) for oxaliplatin-induced peripheral neurotoxicity using the functional assessment of cancer therapy/gynecologic oncology group 12-item neurotoxicity questionnaire in a Phase II, multicenter, randomized, double-blind, placebo-controlled trial."
5.	Lower Urinary Tract Symptoms 03/01/2006 - "It was concluded that Goshajinkigan was effective for pollakisuria with prostatic disease, and the administration of the agent for 8 weeks or longer was needed to improve lower urinary tract symptoms." 06/01/2008 - "We investigated the efficacy of Goshajinkigan in 25 patients with prostatic disease in whom pollakisuria was not improved by treatment with drugs for lower urinary tract symptoms. " 10/01/2015 - "We evaluated the efficacy and tolerability of Hachimi-jio-gan (HJG; bā wèi dì huáng wán) and Gosha-jinki-gan (GJG; jì shēng shèn qì wán), two traditional Japanese medicines, in 60 patients with lower urinary tract symptoms (LUTS) having cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. " 10/01/2015 - "Clinical efficacy and tolerability of two Japanese traditional herbal medicines, Hachimi-jio-gan and Gosha-jinki-gan, for lower urinary tract symptoms with cold sensitivity."

Related Drugs and Biologics

1.	Oxaliplatin (Eloxatin)
2.	Furosemide (Lasix)
3.	Plant Extracts
4.	Type 5 Cyclic Nucleotide Phosphodiesterases
5.	Taxoids (Taxanes)
6.	hange-shashinto
7.	Paclitaxel (Taxol)
8.	liu-jun-zi-tang
9.	bu-zhong-yi-qi-tang
10.	hachimijiogan (TJ 7)

Related Therapies and Procedures

1.	Therapeutics
2.	Kampo Medicine (Kampo)
3.	Drug Therapy (Chemotherapy)
4.	Oral Administration
5.	Glycemic Control