HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

PNU 151807

an alpha-bromoacryloyl derivative of distamycin A; structure in first source

Also Known As:

PNU151807

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Distamycins: 2
    - PNU 151807: 1

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 06/01/1999 - "PNU 151807, like tallimustine, is able to induce an activation of p53, and consequently of p21 and BAX in a human ovarian cancer cell line (A2780) expressing wild-type p53. "
2.	Neoplasms (Cancer) 06/01/1999 - "PNU 151807 possesses a good cytotoxic activity in in vitro growing cancer cells, even superior to that found for tallimustine. " 06/01/1999 - "The results obtained showed that PNU 151807 seems to have a mechanism of action completely different from that of its parent compound tallimustine, possibly involving the inhibition of cyclin-dependent kinases activity, and clearly indicate PNU 151807 as a new non-covalent minor groove binder with cytotoxic activity against cancer cells."

Related Drugs and Biologics

1.	Cyclin-Dependent Kinases (cdk Proteins)
2.	tallimustine