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aggrecanase-1

involved in cleavage of aggrecan at the glutamic acid-373- alanine-374 bond in articular cartilage in arthritic diseases; a disintegrin and metalloprotease with thrombospondin motifs; mutation of the corresponding gene leads to Ehlers-Danlos syndrome type VIIC; RefSeq NM_021599 (human); NM_172845 (mouse)
Also Known As:
ADAMTS-2 protein, human; ADAMTS-2 protein, mouse; ADAMTS-4 protein; ADAMTS4 protein, human; Adamts4 protein, mouse; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 protein, human; a disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif, 4 protein, mouse
Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Morris, Elisabeth A: 2 articles (05/2009 - 11/2002)
2. Kim, Han Sang: 1 article (12/2015)
3. Jung, Jinsei: 1 article (12/2015)
4. Yang, Eun Jin: 1 article (12/2015)
5. Choi, Jae Young: 1 article (12/2015)
6. Lee, Min Goo: 1 article (12/2015)
7. Liu, Chin: 1 article (12/2014)
8. Durbin, Jim D: 1 article (12/2014)
9. Marimuthu, Jothirajah: 1 article (12/2014)
10. Thirunavukkarasu, Kannan: 1 article (12/2014)

Related Diseases

1. Osteoarthritis
2. Inflammation
3. Joint Diseases (Joint Disease)
4. Thoracic Aortic Aneurysm
5. Necrosis

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Cathepsin K
3. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
4. Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
5. licofelone
6. Aggrecans (Aggrecan)
7. Oncostatin M
8. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9. Matrix Metalloproteinase 1 (Interstitial Collagenase)
10. Tissue Inhibitor of Metalloproteinase-3