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GW 311616

structure in first source

Also Known As:

GW311616; GW311616A

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - GW 311616: 4

Experts

1.	An, Weiwei: 1 article (01/2018)
2.	Chen, Jiangyong: 1 article (01/2018)
3.	Chen, Qishan: 1 article (01/2018)
4.	Kyriakides, Maria: 1 article (01/2018)
5.	Maguire, Eithne M: 1 article (01/2018)
6.	Nourshargh, Sussan: 1 article (01/2018)
7.	Pearce, Stuart W A: 1 article (01/2018)
8.	Wen, Guanmei: 1 article (01/2018)
9.	Xiao, Qingzhong: 1 article (01/2018)
10.	Yang, Feng: 1 article (01/2018)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2023 - "Furthermore, GW311616A treatment considerably improved lung function in the COPD mouse model, including preventing the decline of FEV100/FVC and delta PEF as well as inhibiting the increase in FRC, TLC, and FRC/TLC. " 01/01/2023 - "Administration of GW311616A in vivo substantially reduced pulmonary generation of NETs while attenuating the key pathological changes in COPD, including airway leukocyte infiltration, mucus-secreting goblet cell hyperplasia, and emphysema-like alveolar destruction in a mouse model of COPD induced by chronic cigarette smoke exposure. "
2.	Atherosclerosis 01/01/2018 - "In line with these findings, pharmacological inhibition of NE in WT mice through oral administration of NE inhibitor GW311616A also significantly reduced atherosclerosis. " 01/01/2018 - "NE genetic-deficient mice (Apolipoprotein E-/-/NE-/- mice), bone marrow transplantation, and a specific NE inhibitor (GW311616A) were employed in this study to establish the causal role of NE in atherosclerosis. "
3.	Leukemia 09/01/2015 - "These results suggested that NE may promote the development of APL, therefore, NE may be a therapeutic target and its inhibitor GW311616A may be a potential therapeutic drug for leukemia. " 09/01/2015 - "The present study is the first, to the best of our knowledge, to demonstrate that GW311616A, a specific NE inhibitor, may act as a potential targeted drug for leukemia, which may have a profound impact on the future of leukemia-targeted therapy."
4.	Insulin Resistance 04/02/2013 - "NE inhibitor GW311616A reversed insulin resistance and body weight gain in HFD-fed mice. "
5.	Hyperplasia 01/01/2023 - "Administration of GW311616A in vivo substantially reduced pulmonary generation of NETs while attenuating the key pathological changes in COPD, including airway leukocyte infiltration, mucus-secreting goblet cell hyperplasia, and emphysema-like alveolar destruction in a mouse model of COPD induced by chronic cigarette smoke exposure. "

Related Drugs and Biologics

1.	Apolipoproteins
2.	Smoke

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Therapeutics
3.	Oral Administration