lens epithelium-derived growth factor

03/24/2023 - "Surprisingly, we could not detect elevated binding of autoAbs against LEDGF/p75 in cancer patients, but autoAb reactivity to LEDGF/p75 OE cells in about 50% of patients with BPH was unexpectedly significantly increased. "
01/01/2023 - "Here, for the first time, we analyze the role of LEDGF/p75 in multiple cancers via multiple online databases and in vitro experiments. "
01/01/2023 - "However, exploration of LEDGF/p75 as an epigenetic reader of H3K36me3 in tumors is limited. "
01/01/2022 - "Altogether, our data suggest a role of LEDGF/p75 in cancer survival, stem cell renewal, and activation of nuclear super enhancers."
01/01/2016 - "Correction: Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer."

01/01/2016 - "In this study, we found that 1 is selectively effective against hypoxic regions of tumors, and that it directly binds to the transcriptional regulators p54(nrb) and LEDGF/p75, which have not been previously identified as mediators of hypoxia adaptation in cancer cells. "
01/01/2016 - "Furospinosulin-1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia-Adapted Cancer Cells by Binding to Transcriptional Regulators p54(nrb) and LEDGF/p75."

11/21/2003 - "NMDA-induced retinal death and protective effects of LEDGF were evaluated by morphometric analysis, cell numbers in the ganglion cell layer (GCL) and the thickness of the inner plexiform layer (IPL). "
11/21/2003 - "Retinal damage (ganglion and amacrine cells) induced by NMDA was protected by an intravitreal injection of LEDGF."

01/01/2012 - "Here we report the generation of a human somatic LEDGF/p75 knockout cell line that allows the study of spreading HIV-1 infection in the absence of LEDGF/p75. "
01/01/2023 - "Additionally, we observed that the integration cofactor LEDGF/p75 changes distribution upon HIV-1 infection and surrounds the CPSF6/CPSF5 condensates. "
01/01/2022 - "During the early phase of infection, ALLINIs can suppress HIV-1 integration into host genes, which is also observed in LEDGF/p75-depelted cells. "
01/01/2019 - "In the absence of LEDGF/p75, HIV-1 integration and infection efficiency is reduced ten fold. "
01/01/2019 - "During early infection, LEDGINs block the interaction with LEDGF/p75 and allosterically inhibit the catalytic activity of IN (i.e. "

01/01/2019 - "Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection."
01/01/2012 - "Moreover, small molecules that block the LEDGF/p75-IN interaction have recently been developed for the treatment of HIV infection. "
10/25/2016 - "CXCR4 or CCR5 knockout cells generated with this method are resistant to HIV infection in a tropism-dependent manner, whereas knockout of LEDGF or TNPO3 results in a tropism-independent reduction in infection. "
05/01/2012 - "Both stable overexpression of the C-terminal part of LEDGF/p75 (LEDGF(325-530)) containing the integrase (IN)-binding domain (IBD) and stable knockdown (KD) of LEDGF/p75 are known to inhibit HIV infection in laboratory cell lines. "
06/01/2017 - "Through this tethering function LEDGF/p75 is implicated in a diverse set of human diseases including HIV infection and mixed lineage leukemia, an aggressive form of cancer with poor prognosis. "