|1.||Debyser, Zeger: 12 articles (05/2014 - 12/2006)|
|2.||Singh, D P: 11 articles (01/2012 - 01/2000)|
|3.||Shinohara, T: 10 articles (01/2006 - 01/2000)|
|4.||De Rijck, Jan: 8 articles (09/2014 - 12/2006)|
|5.||Gijsbers, Rik: 8 articles (05/2012 - 12/2006)|
|6.||Engelman, Alan: 7 articles (02/2013 - 03/2006)|
|7.||Casiano, Carlos A: 7 articles (05/2012 - 09/2003)|
|8.||Singh, Dhirendra P: 7 articles (01/2011 - 05/2002)|
|9.||Chylack, L T: 7 articles (07/2002 - 01/2000)|
|10.||Christ, Frauke: 6 articles (01/2013 - 12/2006)|
|1.||Ganglion Cysts (Ganglion)
11/21/2003 - "NMDA-induced retinal death and protective effects of LEDGF were evaluated by morphometric analysis, cell numbers in the ganglion cell layer (GCL) and the thickness of the inner plexiform layer (IPL). "
11/21/2003 - "Retinal damage (ganglion and amacrine cells) induced by NMDA was protected by an intravitreal injection of LEDGF."
01/01/2012 - "Here we report the generation of a human somatic LEDGF/p75 knockout cell line that allows the study of spreading HIV-1 infection in the absence of LEDGF/p75. "
12/01/2014 - "LEDGF is a transcription activator that is vital for regulating cell survival during HIV-1 infection. "
08/01/2014 - "Indeed, LEDGF knockout restriction was overcome at a high multiplicity of infection, suggesting alternative mechanisms for HIV-1 genome integration rather than through LEDGF/p75. "
08/01/2014 - "However, residual infection was detected in the LEDGF knockout cells. "
08/01/2014 - "Functional assays revealed that infection with the HIV-1 R5 BaL or X4 NL4-3 viral strains was impaired in LEDGF/p75 knockout cells regardless of entry tropism due to a blockade in HIV-1 proviral integration into the host genome. "
01/01/2012 - "These results further establish LEDGF/p75 as a cancer-related protein, and provide a rationale for ongoing studies aimed at understanding the clinical significance of its expression in specific human cancers."
01/01/2012 - "Expression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types."
03/01/2014 - "Taken together, these results indicate that the E6/E7-dependent maintenance of intracellular LEDGF expression is critical for protecting HPV-positive cancer cells against various forms of cellular stress, including DNA damage. "
03/01/2014 - "Repression of endogenous LEDGF expression by RNA interference results in an increased sensitivity of HPV-positive cancer cells towards genotoxic agents. "
03/01/2014 - "Elevated LEDGF expression has been recently linked to human carcinogenesis and can protect tumor cells towards different forms of cellular stress. "
02/01/2006 - "Gel mobility assay confirmed the binding of LEDGF to the heat shock element (nGAAn) and the stress response element (A/TGGGGA/T) present in gamma-GCS-HS promoter. "
01/20/2006 - "C-terminal LEDGF contains activation domains, an extensive loop-region (aa 418-530) with two helix-turn-helix (HTH)-like domains, and binds to a heat shock element (HSE; nGAAn). "
07/01/2005 - "A gel mobility shift assay demonstrated the attenuation of LEDGF binding to heat shock or stress response elements present in these genes. "
05/01/2002 - "LEDGF is also a transcriptional activator and it binds to promoter elements of heat shock and stress-related genes to activate expression of these genes. "
12/28/2001 - "Mutations in the heat shock element and stress-related elements of the AOP2 promoter reduced LEDGF-dependent trans-activation. "
|5.||Acquired Immunodeficiency Syndrome (AIDS)
01/05/2013 - "Due to its important role in HIV-replication the LEDGF/p75-IN interaction is an attractive antiviral novel target for the treatment of HIV/AIDS. "
01/01/2009 - "Additionally, the targeting of IN cofactors such as LEDGF and Vpr will be discussed as novel strategies for the treatment of AIDS."
05/07/2014 - "LEDGF/p75 is a transcriptional coactivator implicated in the pathogenesis of AIDS and leukemia. "
03/01/2012 - "LEDGF/p75 is also known as the dense fine speckles autoantigen of 70 kDa (DFS70) and has been implicated in cancer, HIV-AIDS, autoimmunity, and inflammation. "
04/01/2009 - "The methods enable (1) the study of interactions between purified recombinant IN and its viral DNA substrates at the molecular level; (2) the identification and characterization of nucleoprotein complexes involved in the human immunodeficiency virus type-1 (HIV-1) concerted integration pathway; (3) the determination of the multimeric state of IN within these complexes; (4) dissection of the interaction between HIV-1 IN and cellular proteins such as lens epithelium-derived growth factor (LEDGF/p75); (5) the examination of HIV-1 Class II and strand transfer inhibitor resistant IN mutants; (6) the mechanisms associated with strand transfer inhibitors directed against HIV-1 IN that have clinical relevance in the treatment of HIV-1/AIDS."
|3.||lens epithelium-derived growth factor
|6.||Proteins (Proteins, Gene)
|8.||Messenger RNA (mRNA)
|9.||Staphylococcal Protein A (A, Protein)
|10.||Rhodopsin (Visual Purple)
|4.||Heterologous Transplantation (Xenotransplantation)