arachidonyl-2-chloroethylamide

a potent and selective agonist of the neuronal cannabinoid receptor; structure in first source

Also Known As:

ACEA cpd; N-(2-chloroethyl)-5,8,11,14-eicosatetraenamide; arachidonyl-2'-chloroethylamide

Networked: 23 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        arachidonyl-2-chloroethylamide: 23
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        arachidonyl-2-chloroethylamide: 23

Experts

1.	Jia, Ji: 2 articles (01/2020 - 01/2018)
2.	Yang, Shuai: 2 articles (01/2020 - 01/2018)
3.	Costa, Andressa P: 2 articles (04/2019 - 01/2018)
4.	Crunfli, Fernanda: 2 articles (04/2019 - 01/2018)
5.	Torrão, Andréa S: 2 articles (04/2019 - 01/2018)
6.	Vrechi, Talita A: 2 articles (04/2019 - 01/2018)
7.	Andres-Mach, Marta: 2 articles (04/2017 - 12/2012)
8.	Haratym-Maj, Agnieszka: 2 articles (04/2017 - 12/2012)
9.	Luszczki, Jarogniew J: 2 articles (12/2012 - 10/2006)
10.	Bermúdez de León, Mario: 1 article (01/2020)

Related Diseases

1.	Overactive Urinary Bladder (Overactive Bladder) 02/14/2023 - "The Cannabinoid Ligand Arachidonyl-2'-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model."
2.	Seizures (Absence Seizure) 10/10/2006 - "The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA; N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, a highly selective cannabinoid CB(1) receptor agonist) on the threshold for electroconvulsions and the anticonvulsant activity of valproate in the maximal electroshock-induced seizures in mice. " 11/15/2016 - "Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice." 12/03/2012 - "The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the protective action of clonazepam, ethosuximide, phenobarbital, and valproate against pentylenetetrazole (PTZ)-induced clonic seizures in mice. "
3.	Hyperalgesia 01/01/2015 - "We investigated the capacity of intrathecal arachidonyl-2'-chloroethylamide (ACEA), a cannabinoid-1 receptor (CB1R) agonist, to inhibit referred hyperalgesia and increased bladder contractility resulting from acute acrolein-induced cystitis in rats. " 11/01/2008 - "In the present study, correlative behavioral and in vivo electrophysiological studies were conducted to determine if peripheral administration of the cannabinoid receptor agonists arachidonyl-2'-chloroethylamide (ACEA) or (R)-(+)-methanandamide (methAEA) could attenuate mechanical allodynia and hyperalgesia, and decrease mechanically evoked responses of Adelta nociceptors. "
4.	Cognitive Dysfunction 01/01/2012 - "The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, reduces the cognitive impairment observed in double AβPP(swe)/PS1(1dE9) transgenic mice from 6 months of age onwards. "
5.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2020 - "In this study, we used oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in neuronal cells and middle cerebral artery occlusion (MCAO)-induced brain IRI in rats to mimic ischemic brain injury, and hypothesized that the CB1 receptor agonist arachidonyl-2-chloroethylamide (ACEA) would protect ischemic neurons by inhibiting mitochondrial fission via dynamin-related protein 1 (Drp1). "

Related Drugs and Biologics

1.	Cannabinoids
2.	Ligands
3.	Corticosterone
4.	CB1 Cannabinoid Receptor (CB1 Receptor)
5.	Valproic Acid (Depakote)
6.	Cannabinoid Receptors (Cannabinoid Receptor)
7.	Glucose (Dextrose)
8.	Anticonvulsants (Antiepileptic Drugs)
9.	Cannabinoid Receptor Agonists
10.	Dynamins (Dynamin)