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methylhistaprodifen

Also Known As:

N(alpha)-methyl-2-(2-(3, 3-diphenylpropyl)-1H-imidazol-4-yl)ethanamine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Biogenic Amines: 992
    - Biogenic Monoamines: 29
      - Histamine: 13775
        Methylhistamines: 1
        methylhistaprodifen: 2
  - Ethylamines: 5
    - Histamine: 13775
      - Methylhistamines: 1
        methylhistaprodifen: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Histamine: 13775
        Methylhistamines: 1
        methylhistaprodifen: 2

Experts

1.	Elz, S: 1 article (07/2001)
2.	Kozłowska, H: 1 article (07/2001)
3.	Kramer, K: 1 article (07/2001)
4.	Kwolek, G: 1 article (07/2001)
5.	Malinowska, B: 1 article (07/2001)
6.	Pertz, H H: 1 article (07/2001)
7.	Schlicker, E: 1 article (07/2001)
8.	Schunack, W: 1 article (07/2001)

Related Diseases

1.

Body Weight (Weight, Body)

07/01/2001 - "In pithed and vagotomized rats, diastolic blood pressure (which was increased to 80-85 mmHg by vasopressin infusion) was decreased dose dependently by methylhistaprodifen (the reference compound) and by compounds 1-4. The maximum decrease was about 47-50 mmHg for methylhistaprodifen and compounds 1, 2 and 3. Their potencies, expressed as pED50 (the negative logarithm of the dose in mole per kilogram body weight that decreased diastolic blood pressure by 25 mmHg), were 8.31, 8.23, 8.26 and 7.84, respectively. "
01/01/1999 - "In pithed, vagotomized rats diastolic blood pressure was decreased by 2-(2-thiazolyl)ethanamine i.v. (which was used as a reference H1-receptor agonist) and by histaprodifen, methylhistaprodifen, and dimethylhistaprodifen; the maximum decrease was about 45 mmHg for each compound, and the potencies, expressed as pED50, the negative logarithm of the dose (in mole per kilogram body weight) eliciting a half-maximal response, were 7.23, 7.55, 8.43 and 8.12, respectively. "

Related Drugs and Biologics

1.	Vasopressins (Vasopressin)
2.	Histamine H1 Receptors (Histamine H1 Receptor)
3.	dimethylhistaprodifen
4.	histaprodifen