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3- (2- (3- guanidino- 2- methyl- 3- oxo- propenyl)- 5- methylphenyl)- N- isopropylidene- 2- methyl- acrylamide dihydrochloride

inhibitor of Na+/H+ exchanger subtype 3; structure in first source

Also Known As:

S 3226; S-3226; S3226

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - Methacrylates: 609
        3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride: 4
- Amidines: 14
  - Guanidines: 29
    - 3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride: 4

Experts

1.	Chan, Leo K Y: 1 article (01/2018)
2.	Leung, Po Sing: 1 article (01/2018)
3.	Ng, Enders K W: 1 article (01/2018)
4.	Wang, Yi: 1 article (01/2018)
5.	Binder, Henry J: 1 article (10/2015)
6.	Nanda Kumar, Navalpur S: 1 article (10/2015)
7.	Rajendran, Vazhaikkurichi M: 1 article (10/2015)
8.	Tse, Chung M: 1 article (10/2015)
9.	Blikslager, Anthony T: 1 article (11/2006)
10.	Moeser, Adam J: 1 article (11/2006)

Related Diseases

1.	Ischemia 12/01/2001 - "Control rats (N = 12) were infused with saline (6.25 mL/kg over 30 min) before occlusion and the compound groups (each N = 12) were infused with S3226 at a dose of 20 mg/kg over 30 minutes either before initiation of ischemia or immediately after release of clamps. " 12/01/2001 - "S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats." 11/01/2006 - "Ischemia-injured tissues treated with mucosal S-3226 or HOE-694 exhibited equivalent reductions in mucosal-to-serosal fluxes of 22Na+ (by approximately 35%) compared with nontreated ischemia-injured control tissues (P < 0.05). " 12/01/2001 - "The aim of this study was to investigate the effects of an intravenous infusion of S3226 (3-[2-(3-guanidino-2-methyl-3-oxopropenyl)-5-methyl-phenyl]-N-isopropylidene-2-methyl-acrylamide dihydrochloride), a selective Na+/H+ exchange subtype 3 (NHE3) blocker, in ischemia-induced ARF in rats. "
2.	Acute Kidney Injury (Acute Renal Failure) 12/01/2001 - "S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats."
3.	Glucose Intolerance 01/01/2018 - "Chronic S3226 treatment diminished postprandial glucose levels and ameliorated glucose intolerance in db/db mice. "
4.	Inflammation (Inflammations) 10/16/2015 - "In contrast, in DSS-induced inflammation, butyrate-, but not HCO3 (-)-dependent Na(+) absorption is present and is inhibited by HOE694, but not by S3226. "

Related Drugs and Biologics

1.	propylene (propene)
2.	3-methylsulfonyl-4-piperidinobenzoyl guanidine
3.	Glucose (Dextrose)
4.	Butyrates (Butyrate)

Related Therapies and Procedures

1.	Intravenous Infusions