5-oxoprolinase (ATP-hydrolyzing)

catalyzes the hydrolysis of 5-oxo-L-proline to glutamate with concomitant stoichiometric cleavage of ATP to ADP & inorganic phosphate in the presence of Mg2+ & K+; EC number in first source

Also Known As:

Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kaufmann, Yihong: 1 article (01/2008)
2.	Klimberg, V Suzanne: 1 article (01/2008)
3.	Luo, Shaoke: 1 article (01/2008)
4.	Todorova, Valentina K: 1 article (01/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1998 - "In colon tissues, there is no significant difference in 5-OPase level between the normal and tumor tissues. " 01/01/1998 - "Examination of paired normal and neoplastic tissues of stomach and lung revealed a significantly lower level of 5-OPase in tumor tissues than in the paired normal tissues. " 01/01/1998 - "First, 5-OPase activity was measured in tissues of tumor-bearing rats, in the peripheral mononuclear cells of normal human subjects, and in surgically resected tumor and the adjacent normal tissues from patients. " 01/01/1998 - "These observations initiated the present study of 5-OPase in experimental models and clinical specimens to investigate the potential role of this enzyme in the selective modulation of GSH in normal and tumor tissues. " 01/01/1998 - "Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione."
2.	Drug-Related Side Effects and Adverse Reactions 04/24/1998 - "This has led to a detailed study of the activating enzyme 5-oxo-L-prolinase, including enzymatic and immunocharacterization, as well as in vitro study of the effect of its modulators on anticancer drug toxicity. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "The activities and messenger RNA levels of gamma-glutamyl transpeptidase (GTP), gamma-glutamylcysteine synthetase (GCS), 5-oxo-L-prolinase (OPase), gamma-glutamyl transferase (GTF), and glutaminase (GLNase) were determined in gut mucosa and breast tumor using specific enzyme assays and semiquantitative reverse transcription polymerase chain reaction. "

Related Drugs and Biologics

1.	Enzymes
2.	Melphalan (Alkeran)
3.	2-oxothiazolidine-4-carboxylic acid
4.	Prodrugs
5.	Cysteine (L-Cysteine)
6.	Alkylating Agents
7.	Glutathione (Reduced Glutathione)
8.	Transferases
9.	Messenger RNA (mRNA)
10.	Ligases (Synthetase)