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S,S'- 1,4- phenylene- bis(1,2- ethanediyl)bis- isothiourea

structure in first source

Also Known As:

PBIT cpd

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea: 3
- Sulfur Compounds: 278
  - Thiourea: 362
    - S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea: 3

Experts

1.	Chen, Tong: 2 articles (12/2016 - 05/2004)
2.	Clinton, Steven K: 1 article (12/2016)
3.	Riedl, Kenneth M: 1 article (12/2016)
4.	Schwartz, Steven J: 1 article (12/2016)
5.	Shi, Ni: 1 article (12/2016)
6.	Zhang, Xiaoli: 1 article (12/2016)
7.	Kresty, Laura A: 1 article (05/2004)
8.	Nines, Ronald G: 1 article (05/2004)
9.	Peschke, Sarah M: 1 article (05/2004)
10.	Stoner, Gary D: 1 article (05/2004)

Related Diseases

1.	Aberrant Crypt Foci 04/01/1999 - "Experiments were designed to study the inhibitory effects of S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT) a selective iNOS-specific inhibitor, measured against formation of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF). "
2.	Esophageal Squamous Cell Carcinoma 12/01/2016 - "The objective of this study was to compare the efficacy and mechanism of lyophilized black raspberries (BRB) versus the combination of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), a selective inducible nitric oxide synthase (iNOS) inhibitor in inhibition of carcinogen-induced esophageal squamous cell carcinoma in rats. "
3.	Neoplasms (Cancer) 05/15/2004 - "On the basis of these observations, we initiated a bioassay to evaluate the ability of S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), a selective iNOS inhibitor, to prevent the progression of esophageal tumors in rats preinitiated with NMBA. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Carcinogens
4.	Azoxymethane
5.	Celecoxib (Celebrex)