|1.||de Villiers, W J: 1 article (06/2001)|
|2.||Burikhanov, R: 1 article (06/2001)|
|3.||McClain, C J: 1 article (06/2001)|
|4.||D'Souza, N B: 1 article (06/2001)|
|5.||Deaciuc, I V: 1 article (06/2001)|
|6.||Sarphie, T G: 1 article (06/2001)|
|7.||Hill, D B: 1 article (06/2001)|
|1.||Septic Shock (Toxic Shock Syndrome)
09/01/1999 - "Two novel caspase inhibitors, (2-indolyl)-carbonyl-Ala-Asp-fluoromethylketone (IDN 1529) and (1-methyl-3-methyl-2-indolyl)-carbonyl-Val-Asp-fluoromethylketone (IDN 1965), were studied in a murine model of endotoxic shock. "
09/01/1999 - "Paradoxically, administration of IDN 1529 but not IDN 1965 led to an increase in the LPS-induced elevation of serum cytokines related directly (IL-1beta, IL-18) or indirectly (IL-1alpha, IL-1Ra) to the action of caspase 1. A process that appears to be distinct from both apoptosis and the release of inflammatory cytokines is a late-acting requirement for lethality in endotoxic shock. "
|3.||Body Weight (Weight, Body)
06/01/2001 - "Rats were fed a high-fat, alcohol-containing liquid diet for 14 weeks, treated with LPS (1.0 mg/kg of body weight, intravenously) or saline, followed by injection of a pan-caspase inhibitor IDN1965; N-[(1,3-dimethylindole-2-carbonyl)-valinyl]-3-amino-4-oxo-5-fluoropentanoic acid; 10 mg/kg of body weight, intraperitoneally or vehicle, and killed. "
|1.||Caspase 1 (ICE Protease)