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dihydroxy-vitamin D3

as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes

Also Known As:

1 alpha, 25-dihydroxy-3-epi-vitamin D3

Networked: 37 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Secosteroids: 22
      - Vitamin D: 33265
        dihydroxy-vitamin D3: 37

Experts

1.	Igarashi, Ko: 1 article (08/2020)
2.	Inada, Masaki: 1 article (08/2020)
3.	Kumai, Jun: 1 article (08/2020)
4.	Miyaura, Chisato: 1 article (08/2020)
5.	Nishizawa, Yasuko: 1 article (08/2020)
6.	Sasagawa, Satoru: 1 article (08/2020)
7.	Watanabe, Kenta: 1 article (08/2020)
8.	Yui, Yoshihiro: 1 article (08/2020)
9.	Al Heialy, Saba: 1 article (01/2020)
10.	Gaudet, Mellissa: 1 article (01/2020)

Related Diseases

1.	Airway Remodeling 01/01/2020 - "1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-β1) or T helper type 1 inflammatory cytokines. "
2.	Decapitation 08/01/1989 - "Fetal decapitation caused a significant (p less than 0.001) fall in the clearance of 45Ca across the placenta (Kmf45Ca), which was significantly (p less than 0.05) reversed after fetal bPTH(1-84) and 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) injection, but not back to normal levels. "
3.	Prostatic Neoplasms (Prostate Cancer) 08/24/2020 - "Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. " 10/01/2007 - "In the current study, we have investigated the potential interplay between S179D PRL and 1,25 dihydroxy vitamin D3 (1,25D) in the inhibition of prostate cancer cell growth by incubating cells under circumstances where each hormone alone has no effect. " 10/01/2007 - "S179D prolactin sensitizes human prostate cancer cells such that physiological concentrations of 1, 25 dihydroxy vitamin D3 result in growth inhibition and cell death."
4.	Rheumatoid Arthritis 10/01/2011 - "Supplementation of 1,25 dihydroxy vitamin D3 in patients with treatment naive early rheumatoid arthritis: a randomised controlled trial." 10/01/2011 - "1,25 dihydroxy vitamin D3 has immunomodulatory functions in rheumatoid arthritis (RA) and is an anti-osteoporotic agent. " 02/01/2019 - "To assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA). " 02/01/2019 - "Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis."
5.	Hypercalcemia (Milk Alkali Syndrome) 11/01/2008 - "Despite significant antiproliferative potential, clinical application of 1,25 dihydroxy vitamin D3 [1,25(OH)2VD3] in the treatment of cancer has been hindered due to the development of hypercalcemia. " 12/16/2018 - "BACKGROUND Calcitriol (1 alpha, 25-dihydroxy vitamin D3) is a good vitamin D supplement but can cause hypercalcemia. " 05/01/1994 - "Hypercalcemia associated with an elevated 1,25 dihydroxy vitamin D3 level and an elevated angiotensin-converting enzyme level in a patient without evidence of sarcoidosis or malignancy."

Related Drugs and Biologics

1.	Calcitriol (Calcijex)
2.	Cytokines
3.	Transforming Growth Factor beta (TGF-beta)
4.	bovine parathyroid hormone
5.	Hormones (Hormone)
6.	Parathyroid Hormone (Parathormone)
7.	Calcium
8.	hydroxide ion
9.	Calcitriol Receptors (Calcitriol Receptor)
10.	Macrophage Colony-Stimulating Factor

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)