|1.||Iwamoto, T: 2 articles (11/2001 - 11/2001)|
|2.||Yasuda, T: 2 articles (11/2001 - 11/2001)|
|3.||Yoshinaga, N: 2 articles (11/2001 - 11/2001)|
|4.||Miki, S: 2 articles (11/2001 - 11/2001)|
|5.||Sato, S: 2 articles (11/2001 - 11/2001)|
|6.||Noguchi, K: 1 article (11/2001)|
|7.||Okamoto, K: 1 article (11/2001)|
|8.||Senba, E: 1 article (11/2001)|
11/01/2001 - "These finding suggest that OT-7100 inhibits hyperalgesia in these animal models possibly by enhancing adenosinergic neurotransmission in the dorsal horn, although we still lack direct evidence for it."
11/01/2001 - "A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception."
01/01/1999 - "These results suggest that OT-7100 is a new type of analgesic with the effect of normalizing the nociceptive threshold in peripheral neuropathic hyperalgesia."
01/01/1999 - "Single oral doses of 3 and 10 mg/kg OT-7100 were effective on the hyperalgesia induced by yeast. "
01/01/1999 - "The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia."
|3.||Diabetic Neuropathies (Diabetic Neuropathy)
11/02/2001 - "Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model."
11/02/2001 - "These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury."
|4.||Neuralgia (Stump Neuralgia)
01/01/1999 - "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain. "
|2.||Aldehyde Reductase (Aldose Reductase)